Connect with us


Mannose Health Benefits





Normally, sugar and cancer go together in a negative way. Because a growing number of studies show sugar feeds cancer1,2,3,4 and plays a role in most chronic disease,5 I typically advise you eliminate refined sugar from your diet. I also recommend you limit your fructose consumption for similar reasons. Even when consumed in the form of whole fruit, fructose may be harmful to your health if eaten excessively.

Now, research out of Scotland suggests a type of sugar called mannose, found in cranberries and other fruits, may be useful in the treatment of certain cancers. In experiments involving lab mice, mannose was shown to interfere with the ability of cancerous tumors to take up glucose. It also boosted the effectiveness of chemotherapy drugs.

Mannose Shown to Suppress Cancer in Lab Mice

While sugar has been shown to fuel cancer growth, a team of European researchers, most of whom represent the Cancer Research UK Beatson Institute for Cancer Research at Scotland’s University of Glasgow, have found quite the opposite.

In experiments involving lab mice, Kevin Ryan, Ph.D., professor of molecular cell biology at the University of Glasgow, and his colleagues found mannose:6,7,8

  • Slowed the growth of multiple cancers, including lung, pancreatic and skin, presumably by interfering with the ability of cancerous tumors to take up glucose
  • Reduced the size of cancerous tumors
  • Boosted the effectiveness of cancer drugs — specifically cisplatin and doxorubicin, two of the most widely used chemotherapy medications
  • Did not affect the weight or health of the mice

Mannose also increased the life span of some of the mice. The results of their research were published in the November 2018 issue of the journal Nature.9 To date, mannose has been used as a natural treatment for cystitis (inflammation of the bladder) and urinary tract infections (UTIs).

After Ryan and his team added mannose to the drinking water of mice suffering from lung, pancreatic or skin cancer, they noticed tumor growth slowed. In addition, they noted no obvious side effects to the mice treated with mannose.

“Tumors need a lot of glucose to grow, so limiting the amount they can use should slow cancer progression,” said Ryan. “The problem is that normal tissues need glucose, as well, so we can’t completely remove it from the body.”10

As such, the researchers had to find a dose of mannose sufficient to block glucose such that it slowed tumor growth, but allowed normal tissues to remain unaffected. “This is early research, but it is hoped that finding this perfect balance means that, in the future, mannose could be given to cancer patients to enhance chemotherapy without damaging their overall health,” Ryan stated.11

Beyond the cancers mentioned above, the team exposed cells from other types of cancer — including bone, bowel, leukemia and ovarian — to mannose. Some of the cancer cells responded well to mannose while others did not. About this, one source noted, “The anticancer potential of mannose appeared to depend on whether an enzyme that breaks down the sugar was present in cells.”12

Should You Use Cranberry Juice to Treat UTIs or Cancer?

Very likely you’ve been told that drinking cranberry juice can soothe cystitis and UTIs. Now, the current research seems to suggest it can be used to treat cancer. As such, you may be thinking about loading up on cranberry juice, which I do not recommend.

First, while the use of mannose to treat bladder and urinary tract issues is well founded, I advise you to avoid cranberry juice as a medical treatment. That’s because you’d have to drink a lot of juice, which is often laden with toxic amounts of sugar.

For those conditions, consult your medical practitioner to ensure an accurate diagnosis and then inquire about the possible use of a mannose-containing supplement. Second, with respect to cancer treatment and mannose, keep in mind this research is preliminary and has yet to be tested on humans.

With respect to that, Ryan commented, “Our next step is investigating why [the] treatment only works in some cells, so that we can [determine] which patients might benefit the most from this approach.” He expressed his desire to see clinical trials begin on mannose “as soon as possible to determine its true potential as a new cancer therapy.”

Martin Ledwick, Cancer Research UK’s head information nurse, joined Ryan in cautioning cancer patients to resist the temptation to self-medicate with mannose. Ledwick said:

“Although these results are very promising for the future of some cancer treatments, this is very early research and has not yet been tested in humans.

Patients should not self-prescribe mannose as there is a real risk of negative side effects that haven’t been tested for yet. It’s important to consult with a doctor before drastically changing your diet or taking new supplements.”

The bottom line is it’s difficult to regulate your body’s glucose levels in a healthy manner through self-experimentation. This is particularly the case if you are dealing with a serious illness like cancer or diabetes. While mannose may be a useful complementary treatment, I also encourage you to:

  • Eat a healthy, whole food diet, which implies avoiding processed foods and sugar, especially soda and sweets
  • Exercise regularly
  • Get at least seven to nine hours of high-quality sleep every night
  • Reach out for or continue receiving treatment from professional health care practitioners who are familiar with your condition and experienced in natural approaches

What Is Mannose and How Does It Work?

As mentioned, mannose is a monosaccharide found in cranberries and other fruits, including apples, blueberries, oranges and peaches. It also resides in vegetables like broccoli, cabbage and green beans.

About this simple sugar, The Clinical Advisor says, “In addition, d-mannose occurs naturally in some cells in the human body and is thought to be a prebiotic, because consumption of d-mannose stimulates and fosters the growth of good bacteria in the digestive tract.”

Beyond its presence in whole foods and your body, mannose also commonly appears in supplement form under the name D-mannose. Although mannose is chemically considered a simple sugar, structurally, it is similar to glucose.

That said, it is absorbed more slowly in your gastrointestinal tract than glucose, which accounts for its lower glycemic index. With respect to this aspect of mannose, The Clinical Advisor notes:

“Compared with actual glucose, which is readily absorbed and has a glycemic index of 100, mannose must first be converted into fructose and then into glucose, significantly blunting the insulin response and reducing its impact on blood sugar levels.

After mannose is absorbed by the gut, it is not stored in the liver like glucose, but is filtered out of the body directly by the kidneys.”

For the experiments in which mannose was given to lab mice afflicted by cancers such as bone, bowel, leukemia and ovarian, mannose was shown to more readily disrupt cells that had lower levels of an enzyme called phosphomannose isomerase (PMI). About the impact of PMI, the study authors stated:

“Cells with low levels of PMI are sensitive to mannose, whereas cells with high levels are resistant. … PMI levels also vary greatly between different patients and different tumor types, indicating that PMI levels could be used as a biomarker to direct the successful administration of mannose. …

[T]he administration of mannose could be a simple, safe and selective therapy in the treatment of cancer, and could be applicable to multiple tumor types.”

Research Validates Mannose for Treating Rare Disease CDG and UTIs

D-mannose has been shown to help in the treatment of a rare disease called carbohydrate-deficient glycoprotein syndrome type 1b (CDG 1b). This condition is passed down through families and is characterized by liver and digestive problems associated with hyperinsulinism and inconstant thrombosis. Beyond that, the condition causes your body’s blood coagulation factors to be decreased.

About CDG 1b and mannose, authors of a 2009 study commented, “In our experience, mannose given orally at least four times per day not only transformed lethal CDG 1b into a treatable disease, but also improved the general condition and digestive symptoms of all reported patients but one.”17

As mentioned, D-mannose is commonly used to prevent and treat UTIs, which are usually caused when E. coli bacteria is transferred from your intestinal tract to your urinary tract. D-mannose is great for UTIs because it attaches to the E. coli bacteria, causing them to stick to each other instead of clinging to the walls of your urinary tract.

Under those conditions, the harmful bacteria can be eliminated from your body during urination. Given the increasing instances of antibiotic resistance, natural remedies for UTIs are imperative.

A 2014 study published in the journal World Journal of Urology found D-mannose powder to be as effective as an antibiotic in treating recurrent UTIs in women. A total of 308 women were divided into three groups:18

  • The first group received 2 grams (g) of D-mannose powder mixed in water daily for six months
  • A second group was given 50 milligrams (mg) of the antibiotic Nitrofurantoin daily
  • The third group was a control group and received no treatment

Of the 98 patients experiencing a recurrent UTI, just 15 percent of them consumed D-mannose, whereas 20 percent took the antibiotic and 61 percent received no treatment.

With respect to the outcomes, the study authors said, “D-mannose powder significantly reduced the risk of recurrent UTI, which was no different from [the] Nitrofurantoin group. More studies will be needed to validate the results … but initial findings show that D-mannose may be useful for UTI prevention.”19

If you have been plagued by recurrent UTIs or bladder inflammation, particularly if you are concerned about antibiotic resistance, now may be the time to talk to your health care practitioner about trying D-mannose. It is generally quite effective for up to 90 percent of UTI cases.

The only exception would be UTIs caused by a bacterium other than E. coli; in that case, you’d be better served to ask your doctor about supplements known to disrupt biofilms.20

Mannose Contributes to the Healing Properties of Aloe Vera

While you probably know aloe vera is beneficial for soothing burns, improving wound healing and inhibiting inflammation, you may not be aware that the major sugar in aloe vera is mannose. In a 1994 study, lab mice receiving 300 mg/kilogram (kg) of mannose-6-phosphate showed improved wound healing compared to those treated with saline controls.

The researchers noted, “This dose also had anti-inflammatory activity.”1` Authors of a 2004 study added, “The clear pulp, also known as inner gel, of [the] Aloe vera L. leaf is widely used in various medical, cosmetic and nutraceutical applications. Many beneficial effects of this plant have been attributed to the polysaccharides present in the pulp.”22

Another source states, “High concentrations of mannan saccharides are available in the gel of aloe plants. Laboratory studies show the effects of glucomannan saccharides signals as they activate the immune response through increased expressions of interleukin-1, interleukin-6 and tumor necrosis factor.”

Cautions About Taking Mannose

While mannose is thought to be well tolerated in most people, I do not recommend supplementing with it if you are pregnant or breastfeeding due to the lack of research validating its safe use. That said, pregnant and breastfeeding moms should be fine consuming mannose-containing foods, assuming it is done in moderation. 

The side effects associated with mannose may include bloating and loose stools. Beyond that, since mannose could make it harder to regulate your blood sugar if you have diabetes, use caution when taking D-mannose supplements if you are diabetic.

While the news about mannose as a potential cancer fighter is encouraging, more research, including clinical trials, is needed to validate its effectiveness. For your safety, always consult a medical professional before taking a new supplement or changing the dosing associated with any of your existing supplements.


Source link

قالب وردپرس


Bill Gates: Third Shot May Be Needed to Combat Coronavirus Variants





With more than 40 million Americans having received at least the first dose of the Pfizer or Moderna vaccine, a third dose may be needed to prevent the spread of new variants of the disease, Bill Gates told CBS News Tuesday.

Gates’ comments come amid growing concern that the current vaccines are not effective against the more contagious Brazilian and South African variants.

Pfizer and Moderna have stated that their vaccines are 95% and 99% effective, respectively, against the initial strain of COVID. However, some scientists have questioned those statements. Additionally, the World Health Organization and vaccine companies have conceded that the vaccines do not prevent people from being infected with COVID or from transmitting it, but are only effective at reducing symptoms.

Gates told CBS Evening News:

“The discussion now is do we just need to get a super high coverage of the current vaccine, or do we need a third dose that’s just the same, or do we need a modified vaccine?”

U.S. vaccine companies are looking at making modifications, which Gates refers to as “tuning.”

People who have had two shots may need to get a third shot and people who have not yet been vaccinated would need the modified vaccine, explained Gates. When asked whether the coronavirus vaccine would be similar to the flu vaccine, which requires yearly boosters, Gates couldn’t rule that out. Until the virus is eradicated from all humans, Gates said, additional shots may be needed in the future.

AstraZeneca in particular has a challenge with the variant,” Gates explained. “And the other two, Johnson & Johnson and Novavax, are slightly less effective, but still effective enough that we absolutely should get them out as fast as we can while we study this idea of tuning the vaccine.”

The Bill & Melinda Gates Foundation is funding the studies being conducted in Brazil and South Africa, CBS News said. The foundation has also invested in the AstraZeneca, Johnson & Johnson and the Novavax vaccines, which are being tested against new variants. Once the AstraZeneca vaccine is approved, the Global Alliance for Vaccine Initiative or GAVI, founded by Gates, will distribute it globally.

“Gates continues to move the goalposts,” said Robert F. Kennedy, Jr., chairman and chief legal counsel of Children’s Health Defense. “Meanwhile the strategies he and others have promoted are obliterating the global economy, demolishing the middle class, making the rich richer and censoring vaccine safety advocates, like me.”

Kennedy said that the exclusive focus on vaccines has prevented the kind of progress required to actually address and recover from the pandemic:

“From the pandemic’s outset, clear-headed people familiar with the challenges inherent in the vaccine model have understood that the path out of crisis would require multiple steps. Those steps would need to include the development and/or identification of therapeutic drugs, the sharing of information among doctors to hone improved treatment models that reduce infection mortality rates below those for flu, and the kind of broad-spectrum long-term herd immunity that protects against mutant strains and that only derives from natural infection.”

Instead, Gates and vaccine makers are proposing a lifetime of boosters, supporting insufficient testing to determine safety and failing to address the inadequate monitoring of vaccine injuries, Kennedy said.

The views and opinions expressed in this article are those of the authors and do not necessarily reflect the views of Children’s Health Defense.

Continue Reading


Young nurse suffers from hemorrhage and brain swelling after second dose of Pfizer’s COVID-19 vaccine





(Natural News) A 28-year-old healthcare worker from the Swedish American Hospital, in Beloit, Wisconsin was recently admitted to the ICU just five days after receiving a second dose of Pfizer’s experimental mRNA vaccine. The previously healthy young woman was pronounced brain dead after cerebral angiography confirmed a severe hemorrhage stroke in her brain stem.

Her family members confirmed that she was “breaking out in rashes” after the vaccine. She also suffered from sudden migraine headaches, and got “sick” after taking the second dose of the vaccine. At the very end, she lost the ability to speak and went unconscious. The migraines, nausea, and loss of speech were all symptoms of a brain bleed and brain swelling, something her family did not understand at the time, and something nobody would expect after vaccination.

While on life support, neurologists used angiography to image the damage inside the brain. They found a subarachnoid hemorrhage, whereas a bulging blood vessel burst in the brain, bleeding out in the space between the brain and the tissue covering the brain. The ensuing swelling cut off oxygen to the brain and caused brain death. On February 10, 2021, Sarah reportedly had “no brain activity.” Some of the woman’s organs are now being procured, so they can be donated to other people around the world.

Doctors warn FDA about COVID vaccines causing autoimmune attacks in the heart and brain

Experimental COVID-19 vaccines may cause inflammation along the cardiovascular system, leading to heart attack and/or stroke. This serious issue was brought forth to the Food and Drug Administration (FDA) by Dr. J. Patrick Whelan, M.D., Ph.D. and further confirmed by cardiothoracic surgeon, Dr. Hooman Noorchashm, M.D., Ph.D. The two doctors warned that a recently-infected patient who is subject to COVID-19 vaccination is likely to suffer from autoimmune attacks along the ACE-2 receptors present in the heart, and in the microvasculature of the brain, liver and kidney. If viral antigens are present in the tissues of recipients at the time of vaccination, the vaccine-augmented immune response will turn the immune system against those tissues, causing inflammation that can lead to blood clot formation.

This severe adverse event is likely cause of death for the elderly who are vaccinated despite recently being infected. There is no adequate screening process to ensure that this autoimmune attack doesn’t occur. The elderly are not the only people vulnerable to vaccine injury and death. Pfizer’s experimental COVID-19 vaccine could be the main cause behind the sudden death of Sarah Sickles, a 28-year-old nurse from Wisconsin. The Vaccine Adverse Events Reporting System has captured five permanent disabilities in Wisconsin, 58 ER visits, and eleven deaths in just one month. This is the first case in Wisconsin of someone under 44 years of age suffering from severe COVID-19 vaccine side effects and death. There are now more than 1,170 deaths recorded in the U.S. related to the experimental mRNA vaccines, a reality that the FDA and CDC continue to ignore.

Continue Reading


Powering hypersonic weapons: US armed forces eyeing dangerous 5G tech





(Natural News) Much of the conversation surrounding the benefits of 5G is geared toward the consumer side of the technology. People will be able to download videos at lightning speed and will be more connected than ever, proponents claim, although there are serious questions regarding its safety. However, some of the most important 5G applications are not civil at all – the technology will be used extensively in the military domain.

Some of its military uses are outlined in the Defense Applications of 5G Network Technology report, which was published by the Defense Science Board. This federal committee gives scientific advice to the Pentagon. Their report states: “The emergence of 5G technology, now commercially available, offers the Department of Defense the opportunity to take advantage, at minimal cost, of the benefits of this system for its own operational requirements.”

The 5G commercial network that is being built by private companies right now can be used by the American military for a much lower cost than if the network had been set up exclusively for military purposes.

Military experts expect the 5G system to play a pivotal role in using hypersonic weapons. For example, it can be used for new missiles that bear nuclear warheads and travel at speeds superior to Mach 5. These hypersonic weapons, which travel at five times the speed of sound and move a mile per second, will be flying at high altitudes on unpredictable flight paths, making them as hard to guide as they will be to intercept.

Huge quantities of data need to be gathered and transmitted in a very short period in order to maneuver these warheads on variable trajectories and allow them to change direction in milliseconds to avoid interceptor missiles.

5G for defense

This type of technology is also needed to activate defenses should we be attacked by a weapon of this type; 5G automatic systems could theoretically handle decisions that humans won’t have enough time to make on their own. Military bases and even cities will have less than a minute to react to incoming hypersonic missiles, and 5G will make it easier to process real time data on trajectories for decision-making.

There are also important uses of this technology in combat. 5G’s ability to simultaneously link millions of transceivers will undoubtedly facilitate communication among military personnel and allow them to transmit photos, maps and other vital information about operations in progress at dizzying speeds to improve situational awareness.

The military can also take advantage of the high-frequency and short-wavelength millimeter wave spectrum used by 5G. Its short range means that it is well suited for smart military bases and command posts because the signal will not propagate too far, making it less likely that enemies will be able to detect it.

When it comes to special forces and secret services, the benefits of 5G are numerous. Its speed and connectivity will allow espionage systems to reach unprecedented levels of efficiency. It will also make drones more dangerous by allowing them to identify and target people using facial recognition and other methods.

Like all technology, 5G will also make us highly vulnerable. The network itself could become an attractive target for cyber-attacks and other acts of war being carried out with cutting-edge weaponry. In fact, the 5G network is already viewed as critical infrastructure and is being carefully protected before it is even fully built.

While the focus on 5G’s dangers to human health and the environment is absolutely warranted, it is also important not to lose sight of the military implications of 5G. After all, it is not just the United States that is developing this technology for military purposes; our enemies, like China and other countries, are also making great strides in this realm.

Continue Reading