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Getting Omega-3 to Omega-6 Ratio Right Is Essential for Health

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Omega-3 fats are essential polyunsaturated fats (PUFAs) your body needs for a wide variety of functions, including proper cell division and function of cell receptors, muscle activity, cognition and heart health.

Importantly, the marine-based omega-3 fats docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) — two long-chained PUFAs found in fatty fish, fish oil and krill oil — are actually cellular components, which makes them all the more crucial for optimal functioning of cells and mitochondria.

DHA is particularly important for your brain, as about 90 percent of the fat in your brain is DHA, while EPA appears to be of particular importance for heart health.

EPA Lowers Cardiovascular Health Risks

For example, recent research1,2,3 involving a proprietary prescription formulation of fish oil called Vascepa — a highly-processed form of EPA — found the drug lowered cardiovascular health risks by 25 percent compared to placebo containing mineral oil. This included heart attacks, strokes, bypass surgery and chest pain requiring hospitalization.

Participants received 4 grams of EPA per day, which is two to four times more EPA than typically given, which supports the prediction that most people need far more omega-3 than currently recommended.

I discuss this in my latest book, “Superfuel,” cowritten with James DiNicolantonio, Pharm. D., who has published a number of papers on omega-3 and the health implications of the ratios between omega-3 and omega-6. Based on his review of the scientific literature, which I’ll review further below, 3 to 4 grams of EPA and DHA appear to be ideal.


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Meanwhile, you only need 1 to 2 grams of whole food-based omega-6 linoleic acid per day (not to be confused with conjugated linoleic acid found in grass fed animal foods), ideally from plant seeds and tree nuts, not vegetable oils, as the oxidized omega-6 in these oils actually contribute to heart disease.4

VITAL Study Confirms Heart Healthy Benefits of Fish Consumption

Another recent omega-3 study,5 funded in part by the National Institutes of Health, followed more than 25,000 individuals aged 50 and older for over five years. Participants were taking either a daily supplement containing 1 gram of marine-based omega-3 and 2,000 IUs of vitamin D, or a placebo. As reported by The Harvard Gazette:6

“For omega-3 fatty acids, the previous randomized trials had largely been in high-risk populations with a history of cardiovascular disease (CVD) or with selected risk factors for CVD. VITAL is the first large-scale randomized trial of marine omega-3s in a general population at ‘usual risk’ of CVD.

It’s also one of the first randomized trials of these supplements in a racially and ethnically diverse study population. Assessing the role of these supplements in a general population free of cardiovascular disease and cancer at baseline fills an important gap in knowledge.”

While omega-3 supplementation led to “only a small, statistically nonsignificant 8 percent reduction” in the primary endpoint of major cardiovascular events (heart disease plus stroke plus total CVD mortality), some of the secondary endpoints showed impressive improvement when viewed separately.

For example, heart attacks alone were reduced by 28 percent in the overall population. The authors suggest the lack of reductions in stroke or CVD mortality “watered down” the results for the primary endpoint of major cardiovascular events. They also found that:

  • Compared to the placebo group, African-Americans who received the supplement had a 77 percent reduction in heart attacks.
  • People with low fish intake also reaped far greater benefits than the population as a whole. Those with the lowest fish intake had a 19 percent reduction in major cardiovascular events (the primary endpoint) and a 40 percent reduction in heart attacks (a secondary endpoint).

Vitamin D Supplementation May Lower Cancer Risk, Even in Short Term

As for vitamin D, the study was not long enough to really identify the impact of supplementation on cancer risk, but after accounting for a latency period, the researchers found a 25 percent reduction in cancer deaths, which clearly would have been greater had the study been longer.

“Laboratory and clinical studies suggest that vitamin D may affect tumor biology, making tumors less invasive, less aggressive and less likely to metastasize.

And if that’s the effect, once there’s already a tumor — diagnosed or not, clinically detected or not — you might see a reduction in cancer death over the course of a five-year trial,” lead author, JoAnn Manson, a Michael and Lee Bell professor of Women’s Health at Harvard Medical School and a professor of epidemiology at the Harvard Chan School, said.7

Processed Seed Oils Contribute to Low-Grade Inflammation

Papers written by DiNicolantonio also reveal the importance of omega-3 for health, and the importance of maintaining the right balance between omega-3 and omega-6. In his editorial, “Importance of Maintaining a Low Omega-6/Omega-3 Ratio for Reducing Inflammation,”8 published in the BMJ journal Open Heart, DiNicolantonio notes:

“The consumption of seed oils high in the omega-6 PUFA linoleic acid contributes to low-grade inflammation, oxidative stress, endothelial dysfunction and atherosclerosis. Moreover, dietary linoleic acid significantly increases cyclooxygenase-2 (COX-2) expression in the aorta, converting arachidonic acid to proinflammatory eicosanoids …

Additionally, there is an arachidonic acid-independent pathway of inflammation promoted by the intake of omega-6 seed oils such as increased production of oxidized linoleic acid metabolites and proinflammatory linoleic acid CYP-eicosanoids.

Oxidized linoleic acid metabolites formed from linoleic acid activate NF-kB and increase proinflammatory cytokines, endothelial adhesion molecules, as well as chemokines, all of which are paramount in the formation of atherosclerosis. Linoleic acid also induces an inflammatory environment in endothelial cells that may increase the risk of coronary heart disease (CHD).

Oxidized linoleic acid metabolites are found at a fiftyfold higher concentration in plasma than arachidonic acid metabolites, suggesting that they are more consequential in CHD and other chronic diseases, and lowering dietary linoleic acid reduces oxidized linoleic acid metabolites in the body.”

In short, while omega-3s have an anti-inflammatory effect, the omega-6 found in seed oils tend to be proinflammatory, largely due to the processing the oils undergo, which oxidize the PUFAs. This is important, as chronic low-grade inflammation is a hallmark of most chronic diseases, including obesity, diabetes, heart disease and cancer.

As noted by DiNicolantonio, research shows that as atherosclerotic lesions become more advanced, the ratio between oxidized and unoxidized linoleic acid increases, suggesting the omega-6 in vegetable oils is a driver of coronary heart disease. He addresses these links more directly in his paper, “Omega-6 Vegetable Oils as a Driver of Coronary Heart Disease: The Oxidized Linoleic Acid Hypothesis.”9

Research has also shown that lowering the omega-6 to omega-3 ratio from 18-to-1 to 3-to-1 reduced the release of a proinflammatory cytokine known as IL-6 when eating a high-saturated-fat diet, suggesting that replacing omega-6 with omega-3 indeed reduces inflammation.

Balancing Your Omega-6 to Omega-3 Ratio May Also Aid Weight Management

In an earlier editorial,10 published in 2016, DiNicolantonio discusses the importance of balancing your omega-6 to omega-3 ratio for the prevention and management of obesity, as the two PUFAs have very different effects not only on inflammation markers but also on body fat. In short, they’re “metabolically and functionally distinct,” and produce very different health impacts. He writes:

“[C]alories from vegetable oils high in linoleic acid … an omega-6 fatty acid, are proinflammatory and thrombogenic, whereas calories from eating fish high in omega-3 fatty acids are anti-inflammatory and antithrombotic …

Furthermore, calories from omega-6 … intake from vegetable oils high in linoleic acid (corn oil, sunflower, safflower, cottonseed, soya bean oil) have different effects on fat tissue development and type than calories from omega-3 fatty acid intake high in α-linolenic acid (ALA) (such as flaxseed oil, canola oil, perilla oil, chia oil) …

The typical Western diet now provides an omega-6 to omega-3 ratio of around 16-to-1. High dietary intake of omega-6 fatty acids as occurs today leads to increases in white adipose tissue and chronic inflammation, which are the ‘hallmarks of obesity.’

Omega-6 and omega-3 fatty acids specifically metabolize to prostaglandins, thromboxane and leukotrienes. Prostaglandin E2 from arachidonic acid leads to differentiation and proliferation of adipose tissue and prostaglandin F2α, also from arachidonic acid, prevents the browning of white adipose tissue, which is the good fat tissue as it increases thermogenesis, burning fat through the release of heat.”

DiNicolantonio also notes that by acting directly on your central nervous system, omega-3 and omega-6 fatty acids influence your food intake and your body’s sensitivity to insulin and leptin — but again in opposite directions.

While omega-6 has been shown to increase insulin and leptin resistance, diabetes and obesity in both rodent and human models, omega-3 has the converse effect, and can help “reverse the dysregulation of this system, improve insulin sensitivity and control body fat,” DiNicolantonio writes, adding “It is therefore essential to return to a balanced dietary omega-6 to omega-3 ratio based on data from evolutionary studies.”

His paper also delves into some of the genetic research showing how omega-3 and omega-6 fats affect genetic expression that directly affects fat storage and thermogenesis (the production of body heat, which affects energy expenditure and fat accumulation).

Dietary Recommendations Are Seriously Distorted on Omega-6

While the American Heart Association (AHA) recommends you to consume 5 to 10 percent of your calories as omega-6 from vegetable oils such as soybean oil, canola, corn, olive, cottonseed, sunflower and peanut oil, research suggests you really need only 1 to 2 grams of linoleic acid per day, and ideally from whole food sources such as whole nuts and seeds.

With the exception of flax, chia and hemp seeds, most other plant seeds have high amounts of omega-6. In a recent interview, DiNicolantonio comments on the discrepancy between conventional recommendations and what nutritional research actually shows:11

“Instead of recommending whole foods, [the AHA] recommends refined oils, which makes absolutely no sense. The Lyon Diet Heart Study12 lowered linoleic acid from over 5 percent to about 3.5 percent [and found] a 70 percent reduction in cardiovascular [problems] and mortality.

There’s actually no evidence to support the AHA or the United States dietary guidelines,13 [which] recommends consuming high amounts of omega-6s from vegetable oils … [T]hese isolated oils … don’t have the natural vitamins and minerals and antioxidants in the coatings around seeds and nuts that give us omega-6 to protect them from oxidizing in our body.

When you consume these isolated oils, even if it’s a cold-pressed omega-6, the acid in your stomach will oxidize those oils and create lipid hydroperoxides and aldehydes. We absorb these and they cause a ton of damage.”

To Protect Your Heart and Brain, Normalize Your Omega-3-to-6 Ratio

Getting back to the issue of heart disease, it’s important to realize that it’s not your total cholesterol or cholesterol per se that causes heart disease. Rather, it’s that the linoleic acid in omega-6-rich vegetable oils gets integrated into your high-density lipoproteins (HDLs), low-density lipoproteins (LDLs) and very low-density lipoproteins (VLDLs), and when it oxidizes, it then causes atherosclerosis, i.e., hardening and narrowing of your arteries.

Linoleic acid also damages the endothelium — the layer of cells lining your blood vessels — thereby allowing LDLs and VLDLs to penetrate into the subendothelium.

This chain of events is also at play in neurodegenerative diseases. The aldehydes created by linoleic acid crosslink tau proteins and create neurofibrillary tangles. As noted by DiNicolantonio, “It has been shown in animal studies that these aldehydes can literally create neurofibrillary tangles that you see in Alzheimer’s disease.

Between 1959 and 2008, the linoleic acid concentration in subcutaneous adipose tissue in Americans increased by about 250 percent,14 from 9.1 percent to 21.5 percent. Since the half-life of linoleic acid is about two years in adipose tissue, this is a reliable marker of intake, and this rise in linoleic acid intake parallels the increase in prevalence of both obesity and diabetes, suggesting the advice to eat more vegetable oils is an unwise one.

As mentioned, the American diet is also extremely lopsided in favor of omega-6 over omega-3, which further worsens the situation, as omega-3 can to some degree ameliorate the damaging effects of oxidized linoleic acid. Rather than a ratio of 16-to-1 in favor of omega-6 (the national average), we need to aim for a ratio of 3-1-to-1. Again, ideal amounts appear to be around:

1 to 2 grams of omega-6 (linoleic acid) from plant seeds and tree nuts, not vegetable oils.

3 to 4 grams of omega-3 (EPA and DHA) in the form of fatty fish, krill oil, or fish oil in which the omega-3s are bound to triglycerides and not ethyl esters. (Ethyl esters are a synthetic substrate created through the micro distillation process of crude fish oil, in which ethanol and/or industrial alcohol is added.

This mix is heat distilled in a vacuum chamber, resulting in a concentrated omega-3 ethyl ester condensate, which are the least bioavailable form of omega-3. This appears to be one of the reasons why many commercial fish oils fail to produce expected health benefits in some studies, so if using fish oil, make sure it’s a triglyceride form.)

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Bill Gates: Third Shot May Be Needed to Combat Coronavirus Variants

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With more than 40 million Americans having received at least the first dose of the Pfizer or Moderna vaccine, a third dose may be needed to prevent the spread of new variants of the disease, Bill Gates told CBS News Tuesday.

Gates’ comments come amid growing concern that the current vaccines are not effective against the more contagious Brazilian and South African variants.

Pfizer and Moderna have stated that their vaccines are 95% and 99% effective, respectively, against the initial strain of COVID. However, some scientists have questioned those statements. Additionally, the World Health Organization and vaccine companies have conceded that the vaccines do not prevent people from being infected with COVID or from transmitting it, but are only effective at reducing symptoms.

Gates told CBS Evening News:

“The discussion now is do we just need to get a super high coverage of the current vaccine, or do we need a third dose that’s just the same, or do we need a modified vaccine?”

U.S. vaccine companies are looking at making modifications, which Gates refers to as “tuning.”

People who have had two shots may need to get a third shot and people who have not yet been vaccinated would need the modified vaccine, explained Gates. When asked whether the coronavirus vaccine would be similar to the flu vaccine, which requires yearly boosters, Gates couldn’t rule that out. Until the virus is eradicated from all humans, Gates said, additional shots may be needed in the future.

AstraZeneca in particular has a challenge with the variant,” Gates explained. “And the other two, Johnson & Johnson and Novavax, are slightly less effective, but still effective enough that we absolutely should get them out as fast as we can while we study this idea of tuning the vaccine.”

The Bill & Melinda Gates Foundation is funding the studies being conducted in Brazil and South Africa, CBS News said. The foundation has also invested in the AstraZeneca, Johnson & Johnson and the Novavax vaccines, which are being tested against new variants. Once the AstraZeneca vaccine is approved, the Global Alliance for Vaccine Initiative or GAVI, founded by Gates, will distribute it globally.

“Gates continues to move the goalposts,” said Robert F. Kennedy, Jr., chairman and chief legal counsel of Children’s Health Defense. “Meanwhile the strategies he and others have promoted are obliterating the global economy, demolishing the middle class, making the rich richer and censoring vaccine safety advocates, like me.”

Kennedy said that the exclusive focus on vaccines has prevented the kind of progress required to actually address and recover from the pandemic:

“From the pandemic’s outset, clear-headed people familiar with the challenges inherent in the vaccine model have understood that the path out of crisis would require multiple steps. Those steps would need to include the development and/or identification of therapeutic drugs, the sharing of information among doctors to hone improved treatment models that reduce infection mortality rates below those for flu, and the kind of broad-spectrum long-term herd immunity that protects against mutant strains and that only derives from natural infection.”

Instead, Gates and vaccine makers are proposing a lifetime of boosters, supporting insufficient testing to determine safety and failing to address the inadequate monitoring of vaccine injuries, Kennedy said.

The views and opinions expressed in this article are those of the authors and do not necessarily reflect the views of Children’s Health Defense.

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Young nurse suffers from hemorrhage and brain swelling after second dose of Pfizer’s COVID-19 vaccine

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(Natural News) A 28-year-old healthcare worker from the Swedish American Hospital, in Beloit, Wisconsin was recently admitted to the ICU just five days after receiving a second dose of Pfizer’s experimental mRNA vaccine. The previously healthy young woman was pronounced brain dead after cerebral angiography confirmed a severe hemorrhage stroke in her brain stem.

Her family members confirmed that she was “breaking out in rashes” after the vaccine. She also suffered from sudden migraine headaches, and got “sick” after taking the second dose of the vaccine. At the very end, she lost the ability to speak and went unconscious. The migraines, nausea, and loss of speech were all symptoms of a brain bleed and brain swelling, something her family did not understand at the time, and something nobody would expect after vaccination.

While on life support, neurologists used angiography to image the damage inside the brain. They found a subarachnoid hemorrhage, whereas a bulging blood vessel burst in the brain, bleeding out in the space between the brain and the tissue covering the brain. The ensuing swelling cut off oxygen to the brain and caused brain death. On February 10, 2021, Sarah reportedly had “no brain activity.” Some of the woman’s organs are now being procured, so they can be donated to other people around the world.

Doctors warn FDA about COVID vaccines causing autoimmune attacks in the heart and brain

Experimental COVID-19 vaccines may cause inflammation along the cardiovascular system, leading to heart attack and/or stroke. This serious issue was brought forth to the Food and Drug Administration (FDA) by Dr. J. Patrick Whelan, M.D., Ph.D. and further confirmed by cardiothoracic surgeon, Dr. Hooman Noorchashm, M.D., Ph.D. The two doctors warned that a recently-infected patient who is subject to COVID-19 vaccination is likely to suffer from autoimmune attacks along the ACE-2 receptors present in the heart, and in the microvasculature of the brain, liver and kidney. If viral antigens are present in the tissues of recipients at the time of vaccination, the vaccine-augmented immune response will turn the immune system against those tissues, causing inflammation that can lead to blood clot formation.

This severe adverse event is likely cause of death for the elderly who are vaccinated despite recently being infected. There is no adequate screening process to ensure that this autoimmune attack doesn’t occur. The elderly are not the only people vulnerable to vaccine injury and death. Pfizer’s experimental COVID-19 vaccine could be the main cause behind the sudden death of Sarah Sickles, a 28-year-old nurse from Wisconsin. The Vaccine Adverse Events Reporting System has captured five permanent disabilities in Wisconsin, 58 ER visits, and eleven deaths in just one month. This is the first case in Wisconsin of someone under 44 years of age suffering from severe COVID-19 vaccine side effects and death. There are now more than 1,170 deaths recorded in the U.S. related to the experimental mRNA vaccines, a reality that the FDA and CDC continue to ignore.

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Powering hypersonic weapons: US armed forces eyeing dangerous 5G tech

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(Natural News) Much of the conversation surrounding the benefits of 5G is geared toward the consumer side of the technology. People will be able to download videos at lightning speed and will be more connected than ever, proponents claim, although there are serious questions regarding its safety. However, some of the most important 5G applications are not civil at all – the technology will be used extensively in the military domain.

Some of its military uses are outlined in the Defense Applications of 5G Network Technology report, which was published by the Defense Science Board. This federal committee gives scientific advice to the Pentagon. Their report states: “The emergence of 5G technology, now commercially available, offers the Department of Defense the opportunity to take advantage, at minimal cost, of the benefits of this system for its own operational requirements.”

The 5G commercial network that is being built by private companies right now can be used by the American military for a much lower cost than if the network had been set up exclusively for military purposes.

Military experts expect the 5G system to play a pivotal role in using hypersonic weapons. For example, it can be used for new missiles that bear nuclear warheads and travel at speeds superior to Mach 5. These hypersonic weapons, which travel at five times the speed of sound and move a mile per second, will be flying at high altitudes on unpredictable flight paths, making them as hard to guide as they will be to intercept.

Huge quantities of data need to be gathered and transmitted in a very short period in order to maneuver these warheads on variable trajectories and allow them to change direction in milliseconds to avoid interceptor missiles.

5G for defense

This type of technology is also needed to activate defenses should we be attacked by a weapon of this type; 5G automatic systems could theoretically handle decisions that humans won’t have enough time to make on their own. Military bases and even cities will have less than a minute to react to incoming hypersonic missiles, and 5G will make it easier to process real time data on trajectories for decision-making.

There are also important uses of this technology in combat. 5G’s ability to simultaneously link millions of transceivers will undoubtedly facilitate communication among military personnel and allow them to transmit photos, maps and other vital information about operations in progress at dizzying speeds to improve situational awareness.

The military can also take advantage of the high-frequency and short-wavelength millimeter wave spectrum used by 5G. Its short range means that it is well suited for smart military bases and command posts because the signal will not propagate too far, making it less likely that enemies will be able to detect it.

When it comes to special forces and secret services, the benefits of 5G are numerous. Its speed and connectivity will allow espionage systems to reach unprecedented levels of efficiency. It will also make drones more dangerous by allowing them to identify and target people using facial recognition and other methods.

Like all technology, 5G will also make us highly vulnerable. The network itself could become an attractive target for cyber-attacks and other acts of war being carried out with cutting-edge weaponry. In fact, the 5G network is already viewed as critical infrastructure and is being carefully protected before it is even fully built.

While the focus on 5G’s dangers to human health and the environment is absolutely warranted, it is also important not to lose sight of the military implications of 5G. After all, it is not just the United States that is developing this technology for military purposes; our enemies, like China and other countries, are also making great strides in this realm.

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