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Scientists fear backlash from gene-edited babies claim could jeopardize research

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Scientists working on the frontiers of medicine fear the uproar over the reported births of gene-edited babies in China could jeopardize promising research into how to alter heredity to fend off a variety of disorders.

Researchers are rapidly learning how to edit DNA to fight such conditions as Huntington’s, Tay-Sachs and hereditary heart disease, conducting legally permissible experiments in lab animals and petri dishes without taking the ultimate step of actually creating babies. Now they worry about a backlash against their work, too.

“The alarmists who claimed that scientists won’t behave responsibly in the development of the next generation of gene editing now have ammunition,” said a dismayed Kyle Orwig, a reproductive specialist at the University of Pittsburgh who hopes to eventually alter sperm production to treat infertility.

He said there is a clear public demand for the kind of research he is doing.

“Families contact me all the time,” he said, including men who can’t produce sperm and aren’t helped by today’s reproductive care.

A Chinese researcher sent a shock wave through the scientific community this week when he claimed to have altered the DNA of embryos in hopes of making them resistant to the AIDS virus. He reported the birth of twin girls and said there may be another pregnancy resulting from his work.

International guidelines for years have said gene editing that can change human heredity — through altered eggs, sperm or embryos — should not be tested in human pregnancies until scientists learn if the practice is safe. One fear is that such experiments could inadvertently damage genes that could then be passed on to future generations.

China has ordered a halt to the seemingly underground experiments by He Jiankui and his team.

Chinese researcher He Jiankui speaks during the Human Genome Editing Conference in Hong Kong on Nov. 28, where his claim that he had helped make the world’s first gene-edited babies shocked scientists and drew widespread condemnation. (Kin Cheung/Associated Press)

“This is what we’re afraid of: Not legitimate scientists — it’s crazy people that would just try it without even worrying about consequences,” said Shoukhrat Mitalipov of the Oregon Health & Science University, who is conducting laboratory-only experiments on how to repair gene defects in human embryos.

If the outcry results in more restrictions being added to the current patchwork of rules on what can be studied and how, the field “will be, probably, thrown back for decades,” he added.

The challenge, said Orwig, is to “convince the community that this is one bad apple but it doesn’t reflect what most people are doing.”

There are multiple kinds of gene editing. Experiments to try to fix damaged genes in children and adults with diseases such as sickle cell are fairly straightforward because that drug-like approach would affect only the patient and not his or her offspring.

Far more contentious is gene editing of the germline, or changing genes in such a way that they will be passed through generations. The big ethical question is whether such tinkering should be restricted to genes that can cause otherwise untreatable disorders, or whether medicine should be free to create designer babies with specific traits, such as high IQ.

“I do think the public is probably open to pretty clearly therapeutic uses of this kind of thing, to prevent transmission of disease. But there’s significant discomfort, if not complete opposition, to enhancement uses,” said Josephine Johnston, an expert on biomedical ethics and policy at the Hastings Center, a bioethics research institute based in Garrison, N.Y.

In a poll last summer, the Pew Research Center found most Americans — about seven in 10 — said changing an unborn baby’s DNA to treat a serious disease the child would otherwise be born with would be appropriate. But support dropped sharply when people were told that it would involve studies with embryos.

And just 19 per cent thought gene editing for such things as enhancing intelligence would be appropriate, Pew found.

How to prove that gene editing is safe enough to legitimately try in human pregnancies is a conundrum, said University of Pennsylvania bioethicist Jonathan Moreno. “No regulator follows that child over a lifetime, much less their progeny,” he noted.

Another question for ethicists: Even if it were deemed safe, is gene editing of embryos really needed given today’s options? Already, families who can afford pricey in vitro fertilization can pay extra to have the embryos genetically tested — and implant only those free of well-known dangerous mutations.

But such pre-implantation diagnosis isn’t an answer for everyone, Johnston cautioned. IVF doesn’t always produce enough embryos for couples to choose among. And as testing uncovers more and more disorders, people will have to understand “there’s not going to be a perfect embryo,” she said.

In Pittsburgh, Orwig sees sperm as offering possibly a more practical first step toward germline editing. Some male infertility is caused by genetic defects that prevent testicular stem cells from properly producing sperm. His team studies infertile men to find culprit genes.

Among his plans: gene-edit stem cells, and implant the repaired ones in infertile mice to see if they produce sperm that lead to healthy baby mice.

The technique could be adjusted so that the genetic change isn’t necessarily passed on to the next generation, he said.

Young women undergoing certain cancer treatments already can store ovarian tissue in hopes of future pregnancy, and Orwig said one day it should be possible to remove, say, a mutation in that tissue that otherwise could spread a family’s breast cancer-causing BRCA mutation.

Meanwhile, careful animal work with sperm could “lay the foundation for how one would do it in humans,” he said. “When societal views change and policies change, we’ll be ready.”

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Bill Gates: Third Shot May Be Needed to Combat Coronavirus Variants

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With more than 40 million Americans having received at least the first dose of the Pfizer or Moderna vaccine, a third dose may be needed to prevent the spread of new variants of the disease, Bill Gates told CBS News Tuesday.

Gates’ comments come amid growing concern that the current vaccines are not effective against the more contagious Brazilian and South African variants.

Pfizer and Moderna have stated that their vaccines are 95% and 99% effective, respectively, against the initial strain of COVID. However, some scientists have questioned those statements. Additionally, the World Health Organization and vaccine companies have conceded that the vaccines do not prevent people from being infected with COVID or from transmitting it, but are only effective at reducing symptoms.

Gates told CBS Evening News:

“The discussion now is do we just need to get a super high coverage of the current vaccine, or do we need a third dose that’s just the same, or do we need a modified vaccine?”

U.S. vaccine companies are looking at making modifications, which Gates refers to as “tuning.”

People who have had two shots may need to get a third shot and people who have not yet been vaccinated would need the modified vaccine, explained Gates. When asked whether the coronavirus vaccine would be similar to the flu vaccine, which requires yearly boosters, Gates couldn’t rule that out. Until the virus is eradicated from all humans, Gates said, additional shots may be needed in the future.

AstraZeneca in particular has a challenge with the variant,” Gates explained. “And the other two, Johnson & Johnson and Novavax, are slightly less effective, but still effective enough that we absolutely should get them out as fast as we can while we study this idea of tuning the vaccine.”

The Bill & Melinda Gates Foundation is funding the studies being conducted in Brazil and South Africa, CBS News said. The foundation has also invested in the AstraZeneca, Johnson & Johnson and the Novavax vaccines, which are being tested against new variants. Once the AstraZeneca vaccine is approved, the Global Alliance for Vaccine Initiative or GAVI, founded by Gates, will distribute it globally.

“Gates continues to move the goalposts,” said Robert F. Kennedy, Jr., chairman and chief legal counsel of Children’s Health Defense. “Meanwhile the strategies he and others have promoted are obliterating the global economy, demolishing the middle class, making the rich richer and censoring vaccine safety advocates, like me.”

Kennedy said that the exclusive focus on vaccines has prevented the kind of progress required to actually address and recover from the pandemic:

“From the pandemic’s outset, clear-headed people familiar with the challenges inherent in the vaccine model have understood that the path out of crisis would require multiple steps. Those steps would need to include the development and/or identification of therapeutic drugs, the sharing of information among doctors to hone improved treatment models that reduce infection mortality rates below those for flu, and the kind of broad-spectrum long-term herd immunity that protects against mutant strains and that only derives from natural infection.”

Instead, Gates and vaccine makers are proposing a lifetime of boosters, supporting insufficient testing to determine safety and failing to address the inadequate monitoring of vaccine injuries, Kennedy said.

The views and opinions expressed in this article are those of the authors and do not necessarily reflect the views of Children’s Health Defense.

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Young nurse suffers from hemorrhage and brain swelling after second dose of Pfizer’s COVID-19 vaccine

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(Natural News) A 28-year-old healthcare worker from the Swedish American Hospital, in Beloit, Wisconsin was recently admitted to the ICU just five days after receiving a second dose of Pfizer’s experimental mRNA vaccine. The previously healthy young woman was pronounced brain dead after cerebral angiography confirmed a severe hemorrhage stroke in her brain stem.

Her family members confirmed that she was “breaking out in rashes” after the vaccine. She also suffered from sudden migraine headaches, and got “sick” after taking the second dose of the vaccine. At the very end, she lost the ability to speak and went unconscious. The migraines, nausea, and loss of speech were all symptoms of a brain bleed and brain swelling, something her family did not understand at the time, and something nobody would expect after vaccination.

While on life support, neurologists used angiography to image the damage inside the brain. They found a subarachnoid hemorrhage, whereas a bulging blood vessel burst in the brain, bleeding out in the space between the brain and the tissue covering the brain. The ensuing swelling cut off oxygen to the brain and caused brain death. On February 10, 2021, Sarah reportedly had “no brain activity.” Some of the woman’s organs are now being procured, so they can be donated to other people around the world.

Doctors warn FDA about COVID vaccines causing autoimmune attacks in the heart and brain

Experimental COVID-19 vaccines may cause inflammation along the cardiovascular system, leading to heart attack and/or stroke. This serious issue was brought forth to the Food and Drug Administration (FDA) by Dr. J. Patrick Whelan, M.D., Ph.D. and further confirmed by cardiothoracic surgeon, Dr. Hooman Noorchashm, M.D., Ph.D. The two doctors warned that a recently-infected patient who is subject to COVID-19 vaccination is likely to suffer from autoimmune attacks along the ACE-2 receptors present in the heart, and in the microvasculature of the brain, liver and kidney. If viral antigens are present in the tissues of recipients at the time of vaccination, the vaccine-augmented immune response will turn the immune system against those tissues, causing inflammation that can lead to blood clot formation.

This severe adverse event is likely cause of death for the elderly who are vaccinated despite recently being infected. There is no adequate screening process to ensure that this autoimmune attack doesn’t occur. The elderly are not the only people vulnerable to vaccine injury and death. Pfizer’s experimental COVID-19 vaccine could be the main cause behind the sudden death of Sarah Sickles, a 28-year-old nurse from Wisconsin. The Vaccine Adverse Events Reporting System has captured five permanent disabilities in Wisconsin, 58 ER visits, and eleven deaths in just one month. This is the first case in Wisconsin of someone under 44 years of age suffering from severe COVID-19 vaccine side effects and death. There are now more than 1,170 deaths recorded in the U.S. related to the experimental mRNA vaccines, a reality that the FDA and CDC continue to ignore.

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Powering hypersonic weapons: US armed forces eyeing dangerous 5G tech

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(Natural News) Much of the conversation surrounding the benefits of 5G is geared toward the consumer side of the technology. People will be able to download videos at lightning speed and will be more connected than ever, proponents claim, although there are serious questions regarding its safety. However, some of the most important 5G applications are not civil at all – the technology will be used extensively in the military domain.

Some of its military uses are outlined in the Defense Applications of 5G Network Technology report, which was published by the Defense Science Board. This federal committee gives scientific advice to the Pentagon. Their report states: “The emergence of 5G technology, now commercially available, offers the Department of Defense the opportunity to take advantage, at minimal cost, of the benefits of this system for its own operational requirements.”

The 5G commercial network that is being built by private companies right now can be used by the American military for a much lower cost than if the network had been set up exclusively for military purposes.

Military experts expect the 5G system to play a pivotal role in using hypersonic weapons. For example, it can be used for new missiles that bear nuclear warheads and travel at speeds superior to Mach 5. These hypersonic weapons, which travel at five times the speed of sound and move a mile per second, will be flying at high altitudes on unpredictable flight paths, making them as hard to guide as they will be to intercept.

Huge quantities of data need to be gathered and transmitted in a very short period in order to maneuver these warheads on variable trajectories and allow them to change direction in milliseconds to avoid interceptor missiles.

5G for defense

This type of technology is also needed to activate defenses should we be attacked by a weapon of this type; 5G automatic systems could theoretically handle decisions that humans won’t have enough time to make on their own. Military bases and even cities will have less than a minute to react to incoming hypersonic missiles, and 5G will make it easier to process real time data on trajectories for decision-making.

There are also important uses of this technology in combat. 5G’s ability to simultaneously link millions of transceivers will undoubtedly facilitate communication among military personnel and allow them to transmit photos, maps and other vital information about operations in progress at dizzying speeds to improve situational awareness.

The military can also take advantage of the high-frequency and short-wavelength millimeter wave spectrum used by 5G. Its short range means that it is well suited for smart military bases and command posts because the signal will not propagate too far, making it less likely that enemies will be able to detect it.

When it comes to special forces and secret services, the benefits of 5G are numerous. Its speed and connectivity will allow espionage systems to reach unprecedented levels of efficiency. It will also make drones more dangerous by allowing them to identify and target people using facial recognition and other methods.

Like all technology, 5G will also make us highly vulnerable. The network itself could become an attractive target for cyber-attacks and other acts of war being carried out with cutting-edge weaponry. In fact, the 5G network is already viewed as critical infrastructure and is being carefully protected before it is even fully built.

While the focus on 5G’s dangers to human health and the environment is absolutely warranted, it is also important not to lose sight of the military implications of 5G. After all, it is not just the United States that is developing this technology for military purposes; our enemies, like China and other countries, are also making great strides in this realm.

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