Connect with us

Health

Trying to bridge the ‘genomic divide’: Lack of Indigenous data a challenge for researchers

Editor

Published

on

[ad_1]

A prominent U.S. senator turned to genetic testing last month to try to prove her claim that she had Indigenous ancestry.

But in assessing Elizabeth Warren’s DNA, the geneticists were forced to use samples from Mexico, Peru and Colombia because there were no samples from American Indigenous peoples in the reference databases. 

Because the data is missing, Indigenous geneticists Krystal Tsosie of Vanderbilt University and Matthew Anderson of Ohio State University argue that Warren’s test results, which showed Native American ancestry six to 10 generations ago, are a reach.

Many more researchers have joined the discussion regarding Warren’s DNA test results, weighing in on the problems inherent in using genetic databases to unearth Indigenous ancestry.

Indigenous data is missing because “Native American groups within the U.S. have not chosen to participate in recent population genetic studies,” wrote Carlos Bustamante, the geneticist studying Warren’s DNA. That information gap for Indigenous groups exists around the world, including Canada. 

“The Warren news was a distraction from the real work,” said Laura Arbour, one of the lead scientists for the Silent Genome project recently funded by Genome Canada and Genome British Columbia. 

Arbour and her colleagues are trying to develop strategies to better engage Indigenous communities in genomic research.

She describes a growing “genomic divide” that reflects the apparently insatiable appetite among people with a European background to give their DNA to large databases in return for predictions regarding future health and well-being.

Precision medicine

Bridging this “genomic divide” will allow Indigenous people to benefit from a future with precision medicine, says Arbour.

The term precision medicine refers to the use of genomic data to predict which drug will work best for each person.

But precision medicine cannot serve Indigenous people if their reference data is missing.

The lack of representation of Indigenous genomes in large databases reflects a general wariness in that group caused in part by historical cases of genetic research gone wrong. 

One study considered by leading geneticists including Roderick McInnes, former institute director in the Canadian Institutes of Health Research, as a game changer involved the Nuu-chah-nulth First Nations on Vancouver Island.

The Nuu-chah-nulth have a high frequency of rheumatoid arthritis. The research team collected DNA samples from approximately half of the First Nations members to study the genetic basis for the disorder.

The genetic determinants of rheumatoid arthritis weren’t found, but that wasn’t the big problem. Researchers sent the DNA samples to external facilities for genetic ancestry studies without the knowledge or consent of the participants.

That action created concern around privacy and possible exploitation through the use of the genetic data for commercial gain, Tsosie and Anderson wrote in a piece posted on The Conversation.

Positive relationships

On the other hand, there are examples of positive relationships between Indigenous groups and non-Indigenous genetic researchers. 

Members of the Gitxsan nation in British Columbia, for instance, told Arbour and her colleagues about the high prevalence of sudden cardiac death in their community.

The Gitxsan not only initiated the research into the genetic cause for this disease but also helped supervise the work through advisory and governance committees.

When geneticists were assessing U.S. Senator Elizabeth Warren’s DNA, they had to use samples from Mexico, Peru and Colombia because there were no samples from American Indigenous peoples in the reference databases. (Charles Krupa/Associated Press)

With that co-operative relationship, the research team found the genetic basis for the prevalence of Long QT syndrome, which can cause sudden cardiac death, in the Gitxsan. A gene mutation was found to be responsible for disrupting normal cardiac rhythm. The Gitxsan could then be effectively treated for Long QT syndrome after that discovery.  

Arbour also sees a need to customize the practices for DNA collection in Indigenous communities so that they maintain control.

One little-known aspect about most genetic testing projects, such as the 1000 Genomes Project or 23andMe, is that they, not the donor, retain ownership of the sample.

Indigenous leaders don’t want this to happen in studies of their people.

DNA obtained from an Indigenous individual should be considered “on loan” to the researcher just for the purpose of the specific research project, says Arbour. Ownership of the sample should be retained by the individual with the future potential to be stored in a “tribal-controlled DNA bank,” she says.

Calls for Indigenous leadership

Indigenous leaders have long recognized the need for Indigenous scientists to take ownership of the research conducted with their DNA.

Writing in the Hill Times last month, Natan Obed, president of the Inuit Tapiriit Kanatami, a national, non-profiit organization representing 60,000 Inuit, said that “Inuit are the most researched people in the world — yet with colonial approaches to research … our role is imagined as marginal and of little value.”

He also recently renewed his call for Inuit leadership in the three major Canadian research agencies: the Canadian Institutes of Health Research, the Natural Sciences and Engineering Research Council of Canada and the Social Sciences and Humanities Research Council of Canada.  

Laura Arbour, one of the lead scientists for the Silent Genome project recently funded by Genome Canada and Genome British Columbia, and her colleagues are trying to develop strategies to better engage Indigenous communities in genomic research. (Brad Lyle, Genome BC)    

Building capacity for Indigenous leadership in genomic research takes time. 

But real change could come through the work of programs like SING, which stands for the Summer Internship for Indigenous Peoples in Genomics.

This educational program initiated at the University of Illinois Urbana-Champaign in 2011 and sponsored by multiple agencies including the National Institutes of Health was geared primarily for Indigenous students in a university undergraduate or graduate degree program in the U.S. but has since spread to Canada and New Zealand. 

The SING workshops aim to give Indigenous students interested in genetic science additional skills and knowledge that would help them move into advisory and leadership roles within genetic research. The workshops of approximately 20 participants have been held annually at multiple U.S. university venues, most recently in Seattle earlier this year.

Katrina Claw, a former SING participant and now a leader of the program in the U.S., says there have been participants from 44 First Nations, including mostly students who are interested in genomic, social and political sciences. 

The SING training workshops include basic scientific methods in DNA sequencing and analysis along with tutorials on the principles of informed consent and ethics relating to DNA data sharing. 

Faculty positions

The Indigenous leader of SING Canada, Kim TallBear, an associate professor in the Faculty of Native Studies at the University of Alberta, says that genomics research must also be taught with the view of correcting the history of disciplinary mistakes made by scientists.

A significant proportion of SING participants enter the program with a background in genomic science or the social and political sciences and with the intention of learning about Indigenous genomics from a “bioethical and decolonizational perspective,” said TallBear.

The goal of the SING workshops is starting to be realized. According to TallBear, Anderson is another great example of someone of Indigenous descent who started with SING as a graduate student, came up through the ranks to become an assistant professor and is already leading discussions around genomic research in Indigenous communities.

[ad_2]

Source link

قالب وردپرس

Health

Bill Gates: Third Shot May Be Needed to Combat Coronavirus Variants

Editor

Published

on

By

With more than 40 million Americans having received at least the first dose of the Pfizer or Moderna vaccine, a third dose may be needed to prevent the spread of new variants of the disease, Bill Gates told CBS News Tuesday.

Gates’ comments come amid growing concern that the current vaccines are not effective against the more contagious Brazilian and South African variants.

Pfizer and Moderna have stated that their vaccines are 95% and 99% effective, respectively, against the initial strain of COVID. However, some scientists have questioned those statements. Additionally, the World Health Organization and vaccine companies have conceded that the vaccines do not prevent people from being infected with COVID or from transmitting it, but are only effective at reducing symptoms.

Gates told CBS Evening News:

“The discussion now is do we just need to get a super high coverage of the current vaccine, or do we need a third dose that’s just the same, or do we need a modified vaccine?”

U.S. vaccine companies are looking at making modifications, which Gates refers to as “tuning.”

People who have had two shots may need to get a third shot and people who have not yet been vaccinated would need the modified vaccine, explained Gates. When asked whether the coronavirus vaccine would be similar to the flu vaccine, which requires yearly boosters, Gates couldn’t rule that out. Until the virus is eradicated from all humans, Gates said, additional shots may be needed in the future.

AstraZeneca in particular has a challenge with the variant,” Gates explained. “And the other two, Johnson & Johnson and Novavax, are slightly less effective, but still effective enough that we absolutely should get them out as fast as we can while we study this idea of tuning the vaccine.”

The Bill & Melinda Gates Foundation is funding the studies being conducted in Brazil and South Africa, CBS News said. The foundation has also invested in the AstraZeneca, Johnson & Johnson and the Novavax vaccines, which are being tested against new variants. Once the AstraZeneca vaccine is approved, the Global Alliance for Vaccine Initiative or GAVI, founded by Gates, will distribute it globally.

“Gates continues to move the goalposts,” said Robert F. Kennedy, Jr., chairman and chief legal counsel of Children’s Health Defense. “Meanwhile the strategies he and others have promoted are obliterating the global economy, demolishing the middle class, making the rich richer and censoring vaccine safety advocates, like me.”

Kennedy said that the exclusive focus on vaccines has prevented the kind of progress required to actually address and recover from the pandemic:

“From the pandemic’s outset, clear-headed people familiar with the challenges inherent in the vaccine model have understood that the path out of crisis would require multiple steps. Those steps would need to include the development and/or identification of therapeutic drugs, the sharing of information among doctors to hone improved treatment models that reduce infection mortality rates below those for flu, and the kind of broad-spectrum long-term herd immunity that protects against mutant strains and that only derives from natural infection.”

Instead, Gates and vaccine makers are proposing a lifetime of boosters, supporting insufficient testing to determine safety and failing to address the inadequate monitoring of vaccine injuries, Kennedy said.

The views and opinions expressed in this article are those of the authors and do not necessarily reflect the views of Children’s Health Defense.

Continue Reading

Health

Young nurse suffers from hemorrhage and brain swelling after second dose of Pfizer’s COVID-19 vaccine

Editor

Published

on

By

(Natural News) A 28-year-old healthcare worker from the Swedish American Hospital, in Beloit, Wisconsin was recently admitted to the ICU just five days after receiving a second dose of Pfizer’s experimental mRNA vaccine. The previously healthy young woman was pronounced brain dead after cerebral angiography confirmed a severe hemorrhage stroke in her brain stem.

Her family members confirmed that she was “breaking out in rashes” after the vaccine. She also suffered from sudden migraine headaches, and got “sick” after taking the second dose of the vaccine. At the very end, she lost the ability to speak and went unconscious. The migraines, nausea, and loss of speech were all symptoms of a brain bleed and brain swelling, something her family did not understand at the time, and something nobody would expect after vaccination.

While on life support, neurologists used angiography to image the damage inside the brain. They found a subarachnoid hemorrhage, whereas a bulging blood vessel burst in the brain, bleeding out in the space between the brain and the tissue covering the brain. The ensuing swelling cut off oxygen to the brain and caused brain death. On February 10, 2021, Sarah reportedly had “no brain activity.” Some of the woman’s organs are now being procured, so they can be donated to other people around the world.

Doctors warn FDA about COVID vaccines causing autoimmune attacks in the heart and brain

Experimental COVID-19 vaccines may cause inflammation along the cardiovascular system, leading to heart attack and/or stroke. This serious issue was brought forth to the Food and Drug Administration (FDA) by Dr. J. Patrick Whelan, M.D., Ph.D. and further confirmed by cardiothoracic surgeon, Dr. Hooman Noorchashm, M.D., Ph.D. The two doctors warned that a recently-infected patient who is subject to COVID-19 vaccination is likely to suffer from autoimmune attacks along the ACE-2 receptors present in the heart, and in the microvasculature of the brain, liver and kidney. If viral antigens are present in the tissues of recipients at the time of vaccination, the vaccine-augmented immune response will turn the immune system against those tissues, causing inflammation that can lead to blood clot formation.

This severe adverse event is likely cause of death for the elderly who are vaccinated despite recently being infected. There is no adequate screening process to ensure that this autoimmune attack doesn’t occur. The elderly are not the only people vulnerable to vaccine injury and death. Pfizer’s experimental COVID-19 vaccine could be the main cause behind the sudden death of Sarah Sickles, a 28-year-old nurse from Wisconsin. The Vaccine Adverse Events Reporting System has captured five permanent disabilities in Wisconsin, 58 ER visits, and eleven deaths in just one month. This is the first case in Wisconsin of someone under 44 years of age suffering from severe COVID-19 vaccine side effects and death. There are now more than 1,170 deaths recorded in the U.S. related to the experimental mRNA vaccines, a reality that the FDA and CDC continue to ignore.

Continue Reading

Health

Powering hypersonic weapons: US armed forces eyeing dangerous 5G tech

Editor

Published

on

By

(Natural News) Much of the conversation surrounding the benefits of 5G is geared toward the consumer side of the technology. People will be able to download videos at lightning speed and will be more connected than ever, proponents claim, although there are serious questions regarding its safety. However, some of the most important 5G applications are not civil at all – the technology will be used extensively in the military domain.

Some of its military uses are outlined in the Defense Applications of 5G Network Technology report, which was published by the Defense Science Board. This federal committee gives scientific advice to the Pentagon. Their report states: “The emergence of 5G technology, now commercially available, offers the Department of Defense the opportunity to take advantage, at minimal cost, of the benefits of this system for its own operational requirements.”

The 5G commercial network that is being built by private companies right now can be used by the American military for a much lower cost than if the network had been set up exclusively for military purposes.

Military experts expect the 5G system to play a pivotal role in using hypersonic weapons. For example, it can be used for new missiles that bear nuclear warheads and travel at speeds superior to Mach 5. These hypersonic weapons, which travel at five times the speed of sound and move a mile per second, will be flying at high altitudes on unpredictable flight paths, making them as hard to guide as they will be to intercept.

Huge quantities of data need to be gathered and transmitted in a very short period in order to maneuver these warheads on variable trajectories and allow them to change direction in milliseconds to avoid interceptor missiles.

5G for defense

This type of technology is also needed to activate defenses should we be attacked by a weapon of this type; 5G automatic systems could theoretically handle decisions that humans won’t have enough time to make on their own. Military bases and even cities will have less than a minute to react to incoming hypersonic missiles, and 5G will make it easier to process real time data on trajectories for decision-making.

There are also important uses of this technology in combat. 5G’s ability to simultaneously link millions of transceivers will undoubtedly facilitate communication among military personnel and allow them to transmit photos, maps and other vital information about operations in progress at dizzying speeds to improve situational awareness.

The military can also take advantage of the high-frequency and short-wavelength millimeter wave spectrum used by 5G. Its short range means that it is well suited for smart military bases and command posts because the signal will not propagate too far, making it less likely that enemies will be able to detect it.

When it comes to special forces and secret services, the benefits of 5G are numerous. Its speed and connectivity will allow espionage systems to reach unprecedented levels of efficiency. It will also make drones more dangerous by allowing them to identify and target people using facial recognition and other methods.

Like all technology, 5G will also make us highly vulnerable. The network itself could become an attractive target for cyber-attacks and other acts of war being carried out with cutting-edge weaponry. In fact, the 5G network is already viewed as critical infrastructure and is being carefully protected before it is even fully built.

While the focus on 5G’s dangers to human health and the environment is absolutely warranted, it is also important not to lose sight of the military implications of 5G. After all, it is not just the United States that is developing this technology for military purposes; our enemies, like China and other countries, are also making great strides in this realm.

Continue Reading

Chat

Trending