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Ketogenic Keys to Unlock the Secrets of Good Fats and Bad Fats

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I’ve previously interviewed James DiNicolantonio, Pharm.D., about his book, “The Salt Fix: Why the Experts Got It All Wrong and How Eating More Might Save Your Life,” where he exposes why we got it wrong about salt and promotes eating healthy real salt.1

“The Salt Fix” is a fascinating book and I encourage you to go pick up a copy and read it. Here, we will focus on our new book, “Superfuel: Ketogenic Keys to Unlock the Secrets of Good Fats, Bad Fats, and Great Health,” which covers the importance of dietary fats, and how to discriminate between healthy and harmful fats.

DiNicolantonio compiled most of the research for this book and invited me to contribute to it, which I was happy to do. Healthy fats are the foundation of my last book, “Fat for Fuel,” and I thought it would be useful to expand on the topic with this book.

“‘Superfuel‘ is the ketogenic diet 2.0,” DiNicolantonio says. “Everyone’s doing keto diets now, where their diets are mostly 70 to 80 percent fat. But, ‘How do we enhance that diet? What are the healthy fats? What type of fat should people be eating since it’s making up the majority of their calories?’

I think a lot of people doing the ketogenic diet are doing some things right, but they’re doing a lot of things wrong … That really was the motivation for this book.”


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What’s Gone Wrong With Our Modern Diet

In a nutshell, “Superfuel” guides you back to a diet closer to what was eaten during Paleolithic times. Just over 100 years ago, Procter & Gamble introduced Crisco as an alternative to butter and lard in 1911, and we began consuming industrial vegetable oils or seed oils that never existed before.

These oils are primarily omega-6 linoleic acid, and damaged omega-6 at that, due to the processing involved. As a result, our omega-6 intake nearly tripled, while our intake of plant- and marine-based omega-3 fat DECREASED tenfold, causing a severe imbalance in our omega-3 to omega-6 ratio, which ideally should be between 1-to-1 and 1-to-5. DiNicolantonio says:

“We’ve had these dramatic changes in our fat intake. They actually changed us from the inside out. Omega-6 isn’t bad as it is an essential fat. It’s only when you isolate it and adulterate and consume it in excessive quantities that it becomes pernicious. We have these bottles of omega-6 now that are … exposed to light, and then we cook with them. That oxidizes the oil further.

Then we consume these isolated oils. They don’t have the natural vitamins and minerals and antioxidants in the coatings around seeds and nuts that gives us omega-6 to protect them from oxidizing in our body.

When you consume these isolated oils, even if it’s a cold-pressed omega-6, the acid in your stomach will oxidize those oils and create lipid hydroperoxides and aldehydes. We absorb these and they cause a ton of damage.”

How Damaged Omega-6 Fat Causes Cellular Damage

Indeed, one of the most significant dangers from consuming processed vegetable oils is that the damaged fats are integrated into your cell membranes, including the mitochondrial membrane, and once these membranes become dysfunctional, complications are sure to follow.

Even if you do not cook with canola oil or some other vegetable oil, there are many other stealth or hidden sources of damaged omega-6s. If you frequent restaurants on a regular basis, for example, you’re virtually guaranteed to be eating a high-omega-6 diet, as most restaurants use vegetable oils in their cooking and baking.

Canola oil is one of the worst oils you can cook with,” DiNicolantonio says. “It causes a ton of oxidation products, because they’re so susceptible to heat due to the double bonds. They put these omega-6 seed oils in bread and in condiments, cereals, pastries and desserts. It’s really everywhere … [and] it’s literally transforming you from the inside-out, because these long-chain omegas get integrated in the cell membrane.

The oxidation products oxidize those fatty acid tails. When you damage those tails in the lipid bilayer, they start to curl upwards. That actually creates a more permeable membrane. You get more things that aren’t supposed to get into the cell and damage the mitochondria, damage the DNA. The fluidity of the cell membrane also goes down.

The fluidity of the cell membrane is extremely important, because you have all these hormone transporters that sit in the cell membrane. When you don’t get enough omega-3s, especially docosahexaenoic acid (DHA), the membranes become very rigid …

Instead of being able to come in and out very easily, because the membrane isn’t fluid, it starts … affecting how things flow into and out of the cell. Your metabolic rate goes down, and you have damage in the cell. It’s a huge issue.”

DHA Is Crucial for Cellular Health

With regards to your mitochondria, these organelles have an inner membrane. Cardiolipin is an important component of this membrane and it needs to be saturated in DHA, which happens to be very susceptible to oxidation. Cardiolipin can be likened to a cellular alarm system that triggers apoptosis (cell death) by signaling caspase-3 when something goes wrong with the cell.

However, if the cardiolipin is not saturated with DHA, it cannot signal caspase-3, and hence apoptosis does not occur. As a result, dysfunctional cells are allowed to continue to grow, which can turn into a cancerous cell. Similarly, in your brain, DHA is used as a signal to stimulate NRF2, heme oxygenase 1 and to upregulate antioxidant enzymes.

“Omega-3s oxidizing in the body is bad, but our bodies kind of know what to do with that signal, whereas omega-6, not so much, because we didn’t have as much during Paleolithic times,” DiNicolantonio says.

Lowering your omega-6 intake is also important for the removal of senescent cells, i.e., aged, damaged or crippled cells that have lost the ability to reproduce. If senescent cells are not removed, they start gunking up the machinery. Fasting is another method that will clear out senescent cells.

Dietary Recommendations Are Way Off on Omega-6

When it comes to omega-6, you really only need 1 to 2 grams of linoleic acid per day. I like my primary sources of omega-6 to be whole foods such as nuts and seeds. With the exception of flax seeds, chia seeds and hemp seeds, most other plant seeds have high amounts of omega-6

Meanwhile, the American Heart Association (AHA) recommends you to consume 5 to 10 percent of your calories as omega-6 from vegetable oils or olive oil. DiNicolantonio explains:

“Instead of recommending whole foods, they recommend oils, which makes absolutely no sense. The Lyon Diet Heart Study2 lowered linoleic acid from over 5 percent to about 3.5 percent [and found] a 70 percent reduction in cardiovascular [problems] and mortality.

There’s actually no evidence to support the AHA or the United States dietary guidelines, [which] recommends consuming high amounts of omega-6s from vegetable oils …

The problem with these industrial seed oils is the processing that occurs to get [the oil] out of the seed. They have to use hexane and deodorize the oil, because it’s so toxic. By the time it makes it to the shelf, you’ve got all these oxidation products, and then you consume it and your body oxidizes it with the acid in your stomach.

These oxidation products are about a fiftyfold higher than the eicosanoids made in your body. They are dramatically more harmful than any of the most harmful eicosanoids, like thromboxane a2 … because they form aldehydes. These aldehydes, like 4-hydroxynonenal … is what actually causes oxidized low-density lipoprotein (LDL).

It binds to the apolipoprotein B (apoB) [and] all apoB-containing lipoproteins. Now, these lipoproteins aren’t recognized by the LDL receptors. They hang out in the blood. It’s really the linoleic acid that gets integrated into high-density lipoprotein (HDL), LDL and very low-density lipoprotein (VLDL), [which then] oxidizes and causes atherosclerosis.

Linoleic acid itself also damages the endothelium and causes an increase in penetration of LDL and VLDL particles into the subendothelium … And then when you get these oxidation products, it’s dramatically more harmful.

This is what’s causing neurodegenerative diseases. Aldehydes can actually crosslink tau protein and create neurofibrillary tangles. It has been shown in animal studies that these aldehydes can literally create neurofibrillary tangles that you see in Alzheimer’s disease.

This is what’s called advanced lipoxidation end-products (ALEs). Most people know about advanced glycation end-products (AGEs), but these ALEs, by far, are much more harmful, and it’s caused by consumption of oxidized omega-6 seed oils.”

Healthy Versus Damaging Omega-3 Fat

It may come as a surprise to learn that all omega-3 sources are not healthy either. Not only is the ratio between omega-3 and omega-6 a primary concern, but industrially processed omega-3 products can also cause problems similar to those caused by too much, and damaged, omega-6. This is a topic we delve deeper into in the book.

For example, about half of all fish oils have problems with oxidation. So, when buying a fish oil supplement, you really need to look for a product that tests the hydro peroxide levels. The lower the level the better, but I would not accept anything over 5 percent.

Many fish oils are also not sourced from wild fish, and that’s another consideration. Ideally, you really want a fish oil obtained from wild-caught fish and not farmed. Also avoid farmed fish such as farmed salmon if you’re using that as a direct omega-3 source.

Many times, farmed salmon are raised on an unnatural diet that raises their fat content to abnormal levels and skews their omega-3 to omega-6 ratio in favor of the latter. They’re also chockfull of toxins. Along with wild-caught salmon, other healthy sources of omega-3 are sardines, anchovies and herring.

In addition to that, there’s the issue of sustainability, where both wild-caught and farmed fish fall short. That’s one of the reasons I like krill oil, because it is the largest biomass in the world, and harvesting is tightly regulated. If you’re a vegan and refuse to eat any animal food at all, your choices become very limited. Perhaps one of the best sources of EPA and DHA for vegans is algal oil.

“Krill is great, because it is very sustainable and has so many advantages compared to just regular fish oil, because the omega-3s are bound to phospholipids,” DiNicolantonio says. “Back in Paleolithic times … we were scavengers. Sites have been discovered from over 2 million years ago with dozens of animal skulls cracked open around them.

The brain is higher in DHA than salmon — up to 30 percent more concentrated. So, our ancient ancestors were able to access and scavenge skulls in the African savanna and get tremendous amounts of DHA. To give you an example, 4 ounces of brain can give you up to 1.5 grams of DHA.

It’s extremely saturated in cholesterol as well. This was a phospholipid-bound DHA that we were getting. And your brain doesn’t absorb DHA without it being bound to phosphatidylcholine … When you’re consuming fish oil, you’ve got to esterify it. You’ve got to attach it to choline, and then you absorb it.

But with krill oil, being bound to the phospholipids, you get twice the absorption of DHA … And then, also, our consumption of ALA was 10 times what it was today. How we used to get omega-3s if we weren’t getting brain or seafood is we were consuming a tremendous amount of plant material.

We were getting 10 to 15 grams of alpha-linolenic acid (ALA). That’s the parent omega-3 in plants. We only get about 2 grams nowadays. If you look at a female of childbearing age, they could convert over 20 percent of their ALA to EPA …

[A woman of childbearing age] can convert almost 10 percent of that ALA to DHA, which is a long-chain marine omega-3. They were getting 1 to 1.5 grams of DHA just from the conversion.”

Bear in mind that these conversion rates are not typical. The average, nonpregnant adult typically converts only 5 percent ALA to EPA and 0.5 percent ALA to DHA.

What’s more, when you go from 15 grams of omega-6 linoleic acid to 30 grams, which we’re consuming nowadays, that reduces your conversion rate of ALA to EPA and DHA by another 40 to 50 percent. Certain nutrients, including magnesium and gamma-linolenic acid (GLA), are also required, so certain nutritional deficiencies play a role in your ability to convert ALA to EPA and DHA as well.

The Importance of Animal-Based Omega-3 in Fat Burning

In regard to the ketogenic diet, most people don’t understand how important omega-3s are to building muscle, improving fitness and burning fat. To give you an example, if you replaced just 6 grams of visible fat in your diet (such as steak) with 6 grams of high-quality fish oil, research shows that in just three weeks you may lose 2 pounds of fat and gain half a pound of muscle. The reason for this is because omega-3 fat, particularly DHA, is the pacemaker of the cell.

“The reason why hummingbirds can beat their wings 80 times a second is because they can saturate their wings with DHA,” DiNicolantonio says. “DHA makes the cell membrane so fluid that molecules, like amino acids, glucose, sodium, potassium, they fly in and out of the cell.

The same thing happens in humans. When you consume a high amount of omega-3s, about 3 to 4 grams, you create a cell membrane that is super saturated DHA, very fluid. Now, your basal metabolic rate goes up 15 percent. Your beta-oxidation in the liver during exercise, your fat burning during exercise goes up by 30 percent. Even at rest, your beta-oxidation goes up by 20 percent.

Long-chain omega-3s are important for ketogenic diets, because you become a better fat-burning machine. It’s affecting the machinery, the beta-oxidation in the liver. It’s improving that by activating genes. And then the other omega-3, the plant omega-3, ALA, is a ketogenic substrate, so it doesn’t get stored like the marine omega-3s. It can be converted into ketones …

Medium-chain triglycerides (MCT) oil is great too for fat loss. Meta-analyses or randomized studies show that MCT oil, compared to long-chain saturated fats — we’re talking about heavy cream and butter —significantly reduces waist circumference and visceral adiposity, because it doesn’t get stored. It gets burned for ketones.

The reason why [marine-based] omega-3s are good for fuel is because it suppresses inflammation in the brain. What happens in a cognitive-declining brain is you’re not able to utilize glucose well, because of the inflammation. DHA helps squelch the inflammation.

Your brain is able to utilize glucose better when you’re consuming more omega-3s. You’re actually able to produce more ketone bodies when you’re consuming both parent omega-3 and the long-chain EPA and DHA. You become a better ketogenic machine when you’re consuming high amounts of omega-3s.”

Mechanisms Behind Omega-3s Ability to Optimize Fat Burning and Build Strength

The mechanism behind these effects is an upregulation of genes that activate beta-oxidation in your liver, allowing you to burn fat more efficiently when you have enough omega-3s in your system. Overall, your basal metabolic rate goes up, because your cell membranes are so fluid, which allows amino acids and glucose to flow into and out of the cells better.

Your inflammation also goes down, and all of this helps optimize your ability to burn fat for fuel. On top of that, omega-3s help synthesize protein, so muscle protein synthesis dramatically increases when you consume 3 to 4 grams of animal-based omega-3 per day — again, because amino acids are able to circulate through the cell very easily when its saturated with DHA.

“Studies have shown in middle-aged adults, as well as in the elderly, consuming 3 grams of DHA [per day] increases muscle strength, increases your maximum amount that you’re able to rep. Your grip strength is improved. This is an important fat to help prevent sarcopenia.

This is a very big issue, where elderly people are not even able to carry a milk carton. Really, the omega-3s are what’s going to hopefully help prevent a lot of the muscle loss during aging.”

Recent Study Supports Our New Book — ‘Superfuel’

After taping this interview, the drug company Amarin issued a press release3 about a new study with fish oil that was just recently completed. They used a new proprietary prescription formulation of fish oil called Vascepa. This is a highly-processed form of EPA.

The drug trial was called REDUCE-IT and it was done for five years. The really unusual result of this trial is that they used high doses — 4 grams per day — which is two to four times as much EPA as is typically done in these types of studies.

What did they find? They found a 25 percent reduction in cardiovascular risks, which far exceeded their expectations and results that are seen with statins. The study only looked at cardiovascular disease but my guess is other degenerative diseases, like Alzheimer’s, diabetes and arthritis, also likely improved. We won’t be able to review the study until it is presented at the American Heart Association’s annual meeting on November 10, 2018.

This study confirmed what we wrote and predicted in our book that will be published on November 13. BUT here is the real kicker, the drug costs $2,500 per year or over $200 per month. Krill and clean fish are far less expensive but you need to approach the 4 grams per day dose to achieve these results, which is the key.

More Information

In closing, this has been but a small sampling of what is covered in greater depth in “Superfuel: Ketogenic Keys to Unlock the Secrets of Good Fats, Bad Fats, and Great Health,” which can be preordered from Amazon or Barnes & Noble. It’s a great complement to “Fat for Fuel,” and will help you clearly understand the benefits of these vitally important fats.

Follow Dr. James DiNicolantonio on Facebook, Twitter, and Instagram for more information. Pick up a copy of his book, “The Salt Fix: Why the Experts Got It All Wrong and How Eating More Might Save Your Life.”


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Bill Gates: Third Shot May Be Needed to Combat Coronavirus Variants

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With more than 40 million Americans having received at least the first dose of the Pfizer or Moderna vaccine, a third dose may be needed to prevent the spread of new variants of the disease, Bill Gates told CBS News Tuesday.

Gates’ comments come amid growing concern that the current vaccines are not effective against the more contagious Brazilian and South African variants.

Pfizer and Moderna have stated that their vaccines are 95% and 99% effective, respectively, against the initial strain of COVID. However, some scientists have questioned those statements. Additionally, the World Health Organization and vaccine companies have conceded that the vaccines do not prevent people from being infected with COVID or from transmitting it, but are only effective at reducing symptoms.

Gates told CBS Evening News:

“The discussion now is do we just need to get a super high coverage of the current vaccine, or do we need a third dose that’s just the same, or do we need a modified vaccine?”

U.S. vaccine companies are looking at making modifications, which Gates refers to as “tuning.”

People who have had two shots may need to get a third shot and people who have not yet been vaccinated would need the modified vaccine, explained Gates. When asked whether the coronavirus vaccine would be similar to the flu vaccine, which requires yearly boosters, Gates couldn’t rule that out. Until the virus is eradicated from all humans, Gates said, additional shots may be needed in the future.

AstraZeneca in particular has a challenge with the variant,” Gates explained. “And the other two, Johnson & Johnson and Novavax, are slightly less effective, but still effective enough that we absolutely should get them out as fast as we can while we study this idea of tuning the vaccine.”

The Bill & Melinda Gates Foundation is funding the studies being conducted in Brazil and South Africa, CBS News said. The foundation has also invested in the AstraZeneca, Johnson & Johnson and the Novavax vaccines, which are being tested against new variants. Once the AstraZeneca vaccine is approved, the Global Alliance for Vaccine Initiative or GAVI, founded by Gates, will distribute it globally.

“Gates continues to move the goalposts,” said Robert F. Kennedy, Jr., chairman and chief legal counsel of Children’s Health Defense. “Meanwhile the strategies he and others have promoted are obliterating the global economy, demolishing the middle class, making the rich richer and censoring vaccine safety advocates, like me.”

Kennedy said that the exclusive focus on vaccines has prevented the kind of progress required to actually address and recover from the pandemic:

“From the pandemic’s outset, clear-headed people familiar with the challenges inherent in the vaccine model have understood that the path out of crisis would require multiple steps. Those steps would need to include the development and/or identification of therapeutic drugs, the sharing of information among doctors to hone improved treatment models that reduce infection mortality rates below those for flu, and the kind of broad-spectrum long-term herd immunity that protects against mutant strains and that only derives from natural infection.”

Instead, Gates and vaccine makers are proposing a lifetime of boosters, supporting insufficient testing to determine safety and failing to address the inadequate monitoring of vaccine injuries, Kennedy said.

The views and opinions expressed in this article are those of the authors and do not necessarily reflect the views of Children’s Health Defense.

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Young nurse suffers from hemorrhage and brain swelling after second dose of Pfizer’s COVID-19 vaccine

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(Natural News) A 28-year-old healthcare worker from the Swedish American Hospital, in Beloit, Wisconsin was recently admitted to the ICU just five days after receiving a second dose of Pfizer’s experimental mRNA vaccine. The previously healthy young woman was pronounced brain dead after cerebral angiography confirmed a severe hemorrhage stroke in her brain stem.

Her family members confirmed that she was “breaking out in rashes” after the vaccine. She also suffered from sudden migraine headaches, and got “sick” after taking the second dose of the vaccine. At the very end, she lost the ability to speak and went unconscious. The migraines, nausea, and loss of speech were all symptoms of a brain bleed and brain swelling, something her family did not understand at the time, and something nobody would expect after vaccination.

While on life support, neurologists used angiography to image the damage inside the brain. They found a subarachnoid hemorrhage, whereas a bulging blood vessel burst in the brain, bleeding out in the space between the brain and the tissue covering the brain. The ensuing swelling cut off oxygen to the brain and caused brain death. On February 10, 2021, Sarah reportedly had “no brain activity.” Some of the woman’s organs are now being procured, so they can be donated to other people around the world.

Doctors warn FDA about COVID vaccines causing autoimmune attacks in the heart and brain

Experimental COVID-19 vaccines may cause inflammation along the cardiovascular system, leading to heart attack and/or stroke. This serious issue was brought forth to the Food and Drug Administration (FDA) by Dr. J. Patrick Whelan, M.D., Ph.D. and further confirmed by cardiothoracic surgeon, Dr. Hooman Noorchashm, M.D., Ph.D. The two doctors warned that a recently-infected patient who is subject to COVID-19 vaccination is likely to suffer from autoimmune attacks along the ACE-2 receptors present in the heart, and in the microvasculature of the brain, liver and kidney. If viral antigens are present in the tissues of recipients at the time of vaccination, the vaccine-augmented immune response will turn the immune system against those tissues, causing inflammation that can lead to blood clot formation.

This severe adverse event is likely cause of death for the elderly who are vaccinated despite recently being infected. There is no adequate screening process to ensure that this autoimmune attack doesn’t occur. The elderly are not the only people vulnerable to vaccine injury and death. Pfizer’s experimental COVID-19 vaccine could be the main cause behind the sudden death of Sarah Sickles, a 28-year-old nurse from Wisconsin. The Vaccine Adverse Events Reporting System has captured five permanent disabilities in Wisconsin, 58 ER visits, and eleven deaths in just one month. This is the first case in Wisconsin of someone under 44 years of age suffering from severe COVID-19 vaccine side effects and death. There are now more than 1,170 deaths recorded in the U.S. related to the experimental mRNA vaccines, a reality that the FDA and CDC continue to ignore.

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Powering hypersonic weapons: US armed forces eyeing dangerous 5G tech

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(Natural News) Much of the conversation surrounding the benefits of 5G is geared toward the consumer side of the technology. People will be able to download videos at lightning speed and will be more connected than ever, proponents claim, although there are serious questions regarding its safety. However, some of the most important 5G applications are not civil at all – the technology will be used extensively in the military domain.

Some of its military uses are outlined in the Defense Applications of 5G Network Technology report, which was published by the Defense Science Board. This federal committee gives scientific advice to the Pentagon. Their report states: “The emergence of 5G technology, now commercially available, offers the Department of Defense the opportunity to take advantage, at minimal cost, of the benefits of this system for its own operational requirements.”

The 5G commercial network that is being built by private companies right now can be used by the American military for a much lower cost than if the network had been set up exclusively for military purposes.

Military experts expect the 5G system to play a pivotal role in using hypersonic weapons. For example, it can be used for new missiles that bear nuclear warheads and travel at speeds superior to Mach 5. These hypersonic weapons, which travel at five times the speed of sound and move a mile per second, will be flying at high altitudes on unpredictable flight paths, making them as hard to guide as they will be to intercept.

Huge quantities of data need to be gathered and transmitted in a very short period in order to maneuver these warheads on variable trajectories and allow them to change direction in milliseconds to avoid interceptor missiles.

5G for defense

This type of technology is also needed to activate defenses should we be attacked by a weapon of this type; 5G automatic systems could theoretically handle decisions that humans won’t have enough time to make on their own. Military bases and even cities will have less than a minute to react to incoming hypersonic missiles, and 5G will make it easier to process real time data on trajectories for decision-making.

There are also important uses of this technology in combat. 5G’s ability to simultaneously link millions of transceivers will undoubtedly facilitate communication among military personnel and allow them to transmit photos, maps and other vital information about operations in progress at dizzying speeds to improve situational awareness.

The military can also take advantage of the high-frequency and short-wavelength millimeter wave spectrum used by 5G. Its short range means that it is well suited for smart military bases and command posts because the signal will not propagate too far, making it less likely that enemies will be able to detect it.

When it comes to special forces and secret services, the benefits of 5G are numerous. Its speed and connectivity will allow espionage systems to reach unprecedented levels of efficiency. It will also make drones more dangerous by allowing them to identify and target people using facial recognition and other methods.

Like all technology, 5G will also make us highly vulnerable. The network itself could become an attractive target for cyber-attacks and other acts of war being carried out with cutting-edge weaponry. In fact, the 5G network is already viewed as critical infrastructure and is being carefully protected before it is even fully built.

While the focus on 5G’s dangers to human health and the environment is absolutely warranted, it is also important not to lose sight of the military implications of 5G. After all, it is not just the United States that is developing this technology for military purposes; our enemies, like China and other countries, are also making great strides in this realm.

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