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Familiar music could give Alzheimer’s patients a cognitive boost, study suggests

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It’s long been known that Alzheimer’s patients often retain musical memories, even when recall of names, faces and places has been lost as the disease relentlessly destroys key areas of the brain.

Now Canadian researchers believe they know why, thanks to the power of MRI brain scanning.

Toronto scientists enrolled 20 people with early-stage Alzheimer’s or mild cognitive impairment in a study to discern what was occurring in their brains while they listened to familiar music and a composition they had never heard before while having MRI scans.

When subjects listened to the previously unknown composition, it lit up a region of the brain known as the temporal lobe, “which is what we would have predicted because that part of the brain gets activated when you listen to anything,” said  Dr. Corinne Fischer, director of the memory disorders clinic at St. Michael’s Hospital and one of the researchers.

But when participants listened to familiar music — from a playlist of songs they had chosen going back at least 20 years — there was a much more extensive pattern of activation of several areas of the brain, including those involved with emotion and the processing of language, movement and memory.

“There’s always been this question of why music and the ability to appreciate music is preserved, even in the latest stages of Alzheimer’s disease,” said Fischer.

“And I think one of the things this tells us is that it may be not so much the music as it is that familiar aspect of the music and the fact that that’s activating parts of the brain that aren’t typically damaged by Alzheimer’s pathology.

“So that’s why even though you might not know your name, you may not know your environment, you may still be able to appreciate a song because it’s activating those areas that are not damaged.”

Michael Thaut, the study’s lead author and a professor of music and neuroscience at the University of Toronto, said it’s common for people in even relatively advanced stages of Alzheimer’s to call to mind the melodies and lyrics of songs from their past, as well as the autobiographical memories attached to the music.

“They remember quite a bit of music,” he said, adding that someone might say “‘Yes, this is Duke Ellington’ or ‘This was my favourite music when I went out with my wife.’

“But up to this point, we had no idea what the brain mechanisms are that drive these very long-lasting memories.”

Canadian researchers suggest people with Alzheimer’s listen to familiar songs of the past each day and try to recall the life events the music evokes. (LightField Studios/Shutterstock)

That’s why the researchers are excited about their findings, which were to be presented Wednesday as a “hot topic” at the Society for Neuroscience conference in San Diego.

“This is the first study that we’re aware of that has actually studied these kinds of mechanisms and has come up with some ideas why the Alzheimer brain can retain music much longer than other stuff,” said Thaut, who designed the research and analysed the data.

“So I think this is a breakthrough study.”

‘Engage your brain in music’

For Colleen Newell, taking part in the research confirmed something she had long suspected — that her memory problems and difficulty with organization were signs of cognitive impairment.

“That’s one reason I went into the study,” said the 60-year-old guitarist, pianist and songwriter, one of about five professional musicians included in the research. “Not only did I recognize I was dropping [forgetting] nouns, but that my mother has Alzheimer’s.

“She’s 80, and she was having similar memory issues at my age. So I wanted to have a baseline to see what was going on.”

As part of the research, subjects were asked to listen to their playlist for an hour a day for three weeks, while trying to recollect associated life events and discussing them with family members or caregivers. They were then cognitively tested and also had their brains scanned again.

“What we found was there was improvement in brain functional connectivity, changes in brain activation and also improvements in memory scores, which told us that by exposing the brain repeatedly to this familiar music, people were actually improving cognitively and there was evidence that their brain was also changing,” said Fischer.

Connectivity is a measure of information flow between different brain regions, an important component of neurological function; enhanced connectivity and the other changes suggest that repeatedly listening to familiar music may give the Alzheimer-affected brain a cognitive boost, said Thaut, calling the results “stunning.”

“So I think we’re sitting on something extremely important.”

Fisher said these are preliminary results that need to be replicated in a much larger study, and future research also needs to determine if the beneficial effects of routinely listening to familiar music persist or are transient.

Still, the researchers hope their findings may offer the basis for a targeted form of music therapy, with a goal of potentially slowing the progression of Alzheimer’s disease and possibly other types of dementia — none of which has an effective pharmaceutical treatment or cure.

“Alzheimer’s disease at this point is non-reversible,” said Thaut, who suggests people with the condition could mimic the study protocol on their own, by listening to familiar songs of the past each day and recalling the life events the music evokes.

“We cannot say you will be healthy,” he said. “But we can say if you engage in that kind of exercise with your family, your friends, with the caregiver, your spouse, even to go to concerts, just engage your brain in music, from the data we have there will be some cognitive benefit.”

While the research found that non-musicians seemed to make more cognitive gains than those who routinely play instruments, Newell said she hopes continuing the study protocol on her own “will bump me up to keep me going.”

“And also it encourages me to listen, just to listen to music,” said Newell, a worship leader at a Toronto Anglican church, whose role includes spiritually based music. “I guess just incorporating it more into my daily life.”

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Post-vaccine surge? Michigan’s spring coronavirus case spike close to previous year’s autumn high

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(Natural News) The spike in new Wuhan coronavirus infections recorded in Michigan over the spring is similar to a spike seen during the 2020 fall season. According to a Wall Street Journal analysis, the state’s daily coronavirus case count averaged more than 7,000 for almost two weeks – before taking a slight dip to 6,891 on April 20. This echoed similar figures back in November and December 2020, which saw sharp rises in infections for those two months before plunging.

Back in autumn of last year, Michigan averaged more than 7,000 cases per day for a span of 10 days. New infections dropped slightly, then briefly spiked as the December holidays approached. It then fell to the low 1,000s for the succeeding two months – until ascending again in March.

According to University of Michigan internal medicine professor Dr. Vikas Parekh, the sudden increase in new infections could be attributed to several factors. Among the factors he cited was re-openings, which increased people’s interactions and mobility. Parekh said the loosened restrictions contributed to the spread of the highly contagious U.K. B117 variant.

“As the B117 variant spreads nationally, we will likely see other stats [with] their own surges – although I hope none are as bad as Michigan,” the professor remarked. He continued: “The milestone just tells us we are not yet in the clear, especially as we still have large portions of our population who are not vaccinated yet.”

Parekh also expressed optimism over the lower daily caseloads the Great Lakes State reported. He said he believes both cases and hospitalizations have plateaued and will likely decline soon. The professor commented: “[COVID-19] positivity has been declining now for one week, which is usually a leading indicator of case decline.”

Meanwhile, the state cited younger populations and youth sports, such as basketball, wrestling and hockey, to increase new COVID-19 infections. Because of this, Gov. Gretchen Whitmer called to suspend youth sports and indoor dining in the state. She also exhorted high schools to conduct remote class sessions for two weeks to curb the spread of the pathogen.

Michigan still experienced the spike in cases despite having one of the highest vaccination rates in the country

During the opening stages of the U.S.’s immunization drive against COVID-19, Michigan boasted of having one of the highest vaccination rates nationwide. A report by Bridge Michigan even noted the initial “frenzy for vaccines” that “far exceeded the state’s limited supply.” But things have appeared to turn around for Michigan, as it now struggles to reach the 70 percent vaccination rate needed for herd immunity.

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Scottish mom’s legs turn into a pair of “giant blisters” after first dose of AstraZeneca’s coronavirus vaccine

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(Natural News) Sarah Beuckmann of Glasgow, Scotland, felt a tingling sensation in her legs and noticed a rash flaring up around her ankles a week after getting her first dose of AstraZeneca’s coronavirus (COVID-19) vaccine on March 18.

She also had flu-like symptoms right after the vaccination.

Beuckmann called her doctor to arrange an appointment the morning she noticed the rash, but by the afternoon her skin was already breaking out into blood-filled blisters. Blisters also appeared on her legs, hands, face, arms and bottom.

“I ended up asking my husband to take me to A&E,” said Beuckmann, referring to “accident and emergency,” the equivalent of an emergency room (ER). “When I got there, my heart rate was sitting at 160bpm, which they were very concerned about. I got put on an ECG machine.”

Doctors determine AstraZeneca’s COVID-19 vaccine triggers the rash

Medics carried out tests for HIV, herpes and other skin conditions to work out what triggered the rash, but all results came back negative. Doctors finally determined that the vaccine caused her rare reaction after carrying out two biopsies.

“Once they found that it was a reaction to the vaccine, they put me on steroids and that really seems to be helping my progress,” said Beuckmann. She had been advised by her doctor not to get the second dose of AstraZeneca’s COVID-19 vaccine because of her reaction.

Beuckmann spent 16 days at Queen Elizabeth University Hospital. She was discharged to recover at home. The 34-year-old mother of one is currently wheelchair-bound due to the bandages on her legs and blisters on the soles of her feet. She may need physiotherapy to help strengthen her leg muscles.

“They are starting to heal and they’re looking a lot better than they were but as the blisters started to get worse, they all sort of merged together,” she said. “I didn’t know what was going on.”

With the blisters merging, her legs have looked like a pair of “giant blisters.” Beuckmann admitted that at one point she feared her legs might have to be amputated.

Dermatologist agrees COVID-19 vaccine causes the blisters

Dr. Emma Wedgeworth, a consultant dermatologist and spokeswoman at the British Skin Foundation, agreed that Beuckmann had likely suffered a reaction to the vaccine.

“Vaccines are designed to activate the immune system. Occasionally people will have quite dramatic activation of their immune systems which, as happened in this case, can manifest in their skin” Wedgeworth told MailOnline. “This poor lady had a very severe reaction, which thankfully is extremely rare.”

It is not clear why Beuckmann, who works in retail, was invited for a vaccine. Scotland’s vaccine rollout was focused on people over the age of 50 when she got vaccinated, although vaccines are available to those who are considered at risk from the virus, or live with someone considered vulnerable.

At least 20 million Briton have had AstraZeneca’s COVID-19 vaccine, which drug regulators say causes a rash in one percent of cases. They say rashes caused by the jab tend to go away within a week.

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Trojan labs? Chinese biotech company offers to build COVID testing labs in six states

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In 2012, BGI acquired Complete Genomics, a DNA sequencing company and equipment maker. The funds for the $117.6 million purchase were raised from Chinese venture capitals. The company has expanded its footprint globally. According to its website, BGI conducts business in more than 100 countries and areas and has 11 offices and labs in the U.S.

People are concerned about China’s access to American DNA data

Some said that with Complete Genomics providing an American base, BGI would have access to more DNA samples from Americans, helping it compile a huge database of genetic information. Some also worried about the protection of the genetic information’s privacy.

According to a 2019 report from the U.S.–China Economic and Security Review Commission (USCC), BGI “has formed numerous partnerships with U.S. healthcare providers and research organizations to provide large-scale genetic sequencing to support medical research efforts,”

There are three main reasons why many people in the biotech community and government have expressed concerns about China’s access to American DNA data.

In the “60 Minutes” interview, Evanina discussed the very likely scenario in which Chinese companies would be able to micro-target American individuals and offer customized preventative solutions based on their DNA.

Evanina asked: “Do we want to have another nation systematically eliminate our healthcare services? Are we okay with that as a nation?”

The second concern is that China may use DNA to track and attack American individuals. As the USCC report states: “China could target vulnerabilities in specific individuals brought to light by genomic data or health records. Individuals targeted in such attacks would likely be strategically identified persons, such as diplomats, politicians, high-ranking federal officials or military leadership.”

The third concern is that China may devise bioweapons to target non-Asians. Steven Mosher, president of the Population Research Institute, discussed it in his article “What Will China Do With Your DNA?” published by The Epoch Times in March 2019.

He wrote: “We know that the Asian genome is genetically distinct from the Caucasian and African in many ways. … Would it be possible to bioengineer a very virulent version of, say, smallpox, that was easily transmitted, fatal to other races, but to which the Chinese enjoyed a natural immunity? … Given our present ability to manipulate genomes, if such a bio-weapon can be imagined, it can probably – given enough time and resources – be realized.”

An article from Technocracy said: “China’s aggressive collection of American DNA should be doubly alarming because it can only spell one ultimate outcome: biowarfare. That is, genetically engineering viruses or other diseases that will be selectively harmful to U.S. populations.”

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