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Resveratrol Causes Rogue Cells to Self-Destruct

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A Swiss study1 involving lab mice suggests the grape constituent resveratrol may be effective in treating lung cancer, at least when administered nasally in high doses. The researchers observed a 45 percent decrease in tumor load in mice treated with resveratrol, noting they also developed fewer and smaller tumors than untreated mice.

Despite the favorable outcome showing resveratrol’s ability to cause rogue cells to self-destruct, more research is needed. This is so mainly because resveratrol, upon ingestion as an oral dose, is metabolized and eliminated within minutes — well before it has time to reach the lungs.

Pterostilbene is another potent plant compound similar to resveratrol that you may want to check out. It is the primary polyphenol antioxidant found in blueberries and although it possesses many similar properties, pterostilbene outperforms resveratrol with its superior bioavailability.

Lung Cancer: The World’s Deadliest Cancer

According to The Global Cancer Observatory, a branch of the World Health Organization (WHO), lung cancer, which is the deadliest form of cancer in the world, has claimed more than 1.7 million lives so far in 2018.2 Deaths from lung cancer outpace those from cancers of the breast, pancreas and prostate combined.

Notably, the American Lung Association suggests smoking contributes to 80 to 90 percent of all lung cancer deaths.3 The U.S. Surgeon General issued a report in 2004 stating men who smoke are 23 times more likely to develop this type of cancer than nonsmokers, whereas female smokers face a 13fold increased risk.4

Even if you have never smoked, you still may be at risk for lung cancer. A 2006 report issued by the U.S. Department of Health and Human Services asserts nonsmokers have a 20 to 30 percent greater chance of developing lung cancer if exposed to secondhand smoke at home or work.5

Given the statistics, there is a clear need to continually emphasize the need to forgo the use of tobacco. If you smoke, this is yet another wake-up call emphasizing the need to quit smoking.

What Is Resveratrol and Why Is It Good for You?

Authors of the Swiss study on resveratrol and lung cancer suggest it is “one of the most studied natural products, notably for its cancer chemoprevention properties.”6 Indeed, more than 11,000 studies involving this compound can be found on the U.S. National Institutes of Health’s (NIH) PubMed.gov website.7

Given the popularity of resveratrol in scientific research, you may wonder why it commands so much attention. The massive interest in resveratrol comes about mainly due to its ability to act as a potent antioxidant. Antioxidants are well-known for their antiaging and health-promoting properties, especially with respect to preventing free radical damage.

As mentioned in the featured video, resveratrol can neutralize and control free radicals, which are generated by your body in the course of normal activities like breathing, exercise and metabolism. An overabundance of free radicals can contribute to aging and a host of diseases.

Specifically, resveratrol is a polyphenol designed to increase the life span of plants through disease resistance and stressors such as disease, drastic climate changes and too much ultraviolet light. As you may imagine, humans face some of those same threats, making resveratrol a potential booster of human, as well as plant, health.

Resveratrol is found in food sources such as blueberries, grape skins, pomegranates, raspberries and red wine, as well as dark chocolate and raw cacao, among other plant-based foods. Lest you think, however, that a few extra glasses of wine would bring about the antiaging and neuroprotective benefits of resveratrol, be advised otherwise.

Gregorio Valdez, Ph.D., associate professor of biological sciences at Virginia Tech Carilion Research Institute and co-author of an earlier study investigating the antiaging potential of resveratrol, notes, “In wine, resveratrol is in such small amounts you could not drink enough of it in your life to have the benefits we found in mice given resveratrol.”8

Because alcohol is a neurotoxin known to damage your brain and organs, I advise you get resveratrol from other food sources or a supplement.

Researchers Cautiously Optimistic About the Effects of Resveratrol on Lung Cancer

As mentioned, research performed by a team of scientists from the University of Geneva (UNIGE) in Switzerland involving the administration of resveratrol to lab mice suggests it may be useful in treating lung cancer.

“We tried to prevent lung cancer induced by a carcinogen found in cigarette smoke by using resveratrol … in a mouse model,” said Muriel Cuendet, Ph.D., associate professor in the school of pharmaceutical sciences at UNIGE.9

The study featured four groups of mice treated three times a week for 25 weeks: an untreated control group, a second group receiving just the carcinogen, a third group getting both the carcinogen and resveratrol treatment and a fourth given resveratrol only.

Given the positive outcomes, Cuendet said, “Resveratrol could therefore play a preventive role against lung cancer.”11 The resveratrol solution given equated to about 1.2 milligrams (mg) per mouse or about 60 mg per kilogram. In terms of outcomes, the researchers observed:10

  • The resveratrol-treated mice showed a 27 percent decrease in tumor multiplicity and developed smaller tumors than the untreated mice
  • A 45 percent decrease in tumor load per mouse in the treated mice
  • When comparing the two groups that were not exposed to the carcinogen, 63 percent of the resveratrol-treated mice failed to develop cancer, compared to just 13 percent of the untreated mice
  • In vitro experiments suggest resveratrol’s chemoprevention mechanism is most likely related to apoptosis (programmed cell death), a process known to destroy rogue cells

Resveratrol’s Low Bioavailability Limits Its Effectiveness When Taken Orally

Despite the results with lab mice, it is unclear if resveratrol would have the same effects in humans afflicted with lung cancer, mainly because of how quickly it is metabolized and eliminated — well before it could reach the lungs. About resveratrol’s low bioavailability, the author of a 2011 study published in the Annals of the New York Academy of Sciences stated:12

“The oral absorption of resveratrol in humans is about 75 percent and is thought to occur mainly by transepithelial diffusion. Extensive metabolism in the intestine and liver results in an oral bioavailability considerably less than 1 percent. Dose escalation and repeated dose administration of resveratrol does not appear to alter this significantly.

Metabolic studies, both in plasma and in urine, have revealed major metabolites to be glucuronides and sulfates of resveratrol. However, reduced dihydroresveratrol conjugates, in addition to highly polar unknown products, may account for as much as 50 percent of an oral resveratrol dose.

Although major sites of metabolism include the intestine and liver (as expected), colonic bacterial metabolism may be more important than previously thought.”

With that in mind, Aymeric Monteillier, a scientist in the UNIGE school of pharmaceutical sciences and lead study author of the current research, commented, “This is why our challenge was to find a formulation in which resveratrol could be solubilized in large quantities, even though it is poorly soluble in water, in order to allow nasal administration.”13

Monteillier went on to suggest this mouse-tested formulation could be applicable to humans and may possibly allow the compound to reach human lungs.

Underscoring the benefits of an alternative method of administration, the UNIGE researchers noted the resveratrol concentration obtained in the lungs of mice after nasal administration was 22 times higher than what would have been found if the treatment had been given orally.14

Health Benefits Associated With Resveratrol

Previous studies suggest resveratrol may benefit your health in the following ways:






Combats free radicals15


Improves brain blood flow and suppresses brain inflammation16


Contains antimicrobial and antioxidant properties17,18


May protect against depression19,20


Delivers antiaging effects21


Mimics the effects of calorie restriction22


Enhances learning and memory23


Provides neuroprotective benefits24,25

Best Sources of Resveratrol

While resveratrol can be sourced in small amounts from the foods mentioned previously, muscadine grapes contain the highest concentration — most especially in the skin and seeds. As noted, blueberries and raspberries are other sources.

Due to the fact whole fruit contains fructose, be sure to moderate your intake to ensure you consume less than 25 mg of fructose a day if you are healthy. If you are dealing with a chronic illness like cancer or diabetes, you’ll want to further restrict your daily fructose intake to 15 mg or less until your health improves.

Because it is unlikely you will be able to get therapeutic amounts of resveratrol from food, you might consider adding a whole food resveratrol supplement. I regularly take one that features both grape seed extract and grape skin extract from muscadine grapes.

One serving of that supplement, which contains 50 mg of resveratrol, contains the same amount of resveratrol you’d find in 39 eight-ounce glasses of wine. To prevent your body from developing a tolerance to resveratrol, I recommend you cycle it — consuming it on weekdays, for example, and taking a break from it on weekends.

What’s Next for Resveratrol Research and Lung Cancer?

Now that the intranasal method of administration has been established, the UNIGE team is moving on to identify a potential biomarker that will support them in selecting people eligible for preventive treatment with resveratrol.

As noted by the study authors, “This study presents an effective way to overcome [resveratrol’s] low oral bioavailability, encouraging a reevaluation of its use in future clinical trials.”26

Interestingly, the scientists suggest resveratrol could potentially benefit current and former smokers were it to be successfully developed for use in nebulizers and e-cigarettes. Given the health hazards associated with them, I cannot recommend e-cigarettes or vaping as safe alternatives to smoking. That said, the researchers commented:27

“For ex-smokers, one could easily imagine a nebulizer similar to those used for beta-2-sympathomimetic administration in asthma …

A [resveratrol] containing electronic cigarette could combine the advantage of pharmacological cancer chemopreventive activity with promotion of the transition from conventional tobacco products to electronic cigarettes.”

An Alternative to Resveratrol: Pterostilbene May Be Even Better

Besides resveratrol, a lesser-known inflammation fighter called pterostilbene also deserves attention. It is the predominant polyphenol antioxidant found in blueberries. Similar to resveratrol, pterostilbene is a stilbene but it has far superior bioavailability.

While resveratrol is considered to be about 20 to 25 percent bioavailable, pterostilbene is known for its 80 percent bioavailability, meaning your body can use it more effectively and efficiently.28 Some experts suggest the two compounds are better when consumed together, noting they will act synergistically to boost your health and help prevent disease. About pterostilbene, authors of a 2013 study designed to review its antioxidant properties stated:29,30

“The antioxidant activity of pterostilbene has been implicated in anticarcinogenesis, modulation of neurological disease, anti-inflammation, attenuation of vascular disease and amelioration of diabetes.

Substantial evidence suggests that pterostilbene may have numerous preventive and therapeutic properties in a vast range of human diseases that include neurological, cardiovascular, metabolic and hematologic disorders.

Further benefits of pterostilbene have been reported in preclinical trials, in which pterostilbene was shown to be a potent anticancer agent in several malignancies.”

In terms of pterostilbene’s value as an anticancer compound, the researchers said:31

“Studies suggest pterostilbene exhibits the hallmark characteristics of an effective anticancer agent based on its antineoplastic properties in several common malignancies. In vitro models have shown pterostilbene inhibits cancer growth through alteration of the cell cycle, induction of apoptosis and inhibition of metastasis.

In vivo, pterostilbene inhibits tumorigenesis and metastasis with negligible toxicity. Pterostilbene has also been shown to be effective as an inducer of antioxidant capacity in multiple cancer cell lines that may facilitate its function as an anticarcinogenic compound.

Additionally, preliminary studies show pterostilbene exhibits much greater bioavailability compared [to] other stilbene compounds.”

Before You Begin Taking Resveratrol and Pterostilbene, Talk to Your Health Care Provider

Beyond the benefits already mentioned, a study published in the journal Evidence-based Complementary and Alternative Medicine32 suggests when given in daily doses of 250 mg, pterostilbene also can be useful to lower your blood pressure. Additionally, it has been shown to reduce anxiety in experiments involving lab mice.33

While the news about resveratrol and pterostilbene seems promising, more research is needed to validate the true extent of their health-benefiting potential. Before you begin taking either or both of them in supplement form, I suggest you talk to your health care practitioner first.

As you may imagine, taking any supplement indiscriminately is unlikely to have beneficial effects. Why? Because your body does best when it receives the right nutrients at the right time, in the right amount. Keep that guiding principle in mind as you seek to take control of your health.

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Post-vaccine surge? Michigan’s spring coronavirus case spike close to previous year’s autumn high

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(Natural News) The spike in new Wuhan coronavirus infections recorded in Michigan over the spring is similar to a spike seen during the 2020 fall season. According to a Wall Street Journal analysis, the state’s daily coronavirus case count averaged more than 7,000 for almost two weeks – before taking a slight dip to 6,891 on April 20. This echoed similar figures back in November and December 2020, which saw sharp rises in infections for those two months before plunging.

Back in autumn of last year, Michigan averaged more than 7,000 cases per day for a span of 10 days. New infections dropped slightly, then briefly spiked as the December holidays approached. It then fell to the low 1,000s for the succeeding two months – until ascending again in March.

According to University of Michigan internal medicine professor Dr. Vikas Parekh, the sudden increase in new infections could be attributed to several factors. Among the factors he cited was re-openings, which increased people’s interactions and mobility. Parekh said the loosened restrictions contributed to the spread of the highly contagious U.K. B117 variant.

“As the B117 variant spreads nationally, we will likely see other stats [with] their own surges – although I hope none are as bad as Michigan,” the professor remarked. He continued: “The milestone just tells us we are not yet in the clear, especially as we still have large portions of our population who are not vaccinated yet.”

Parekh also expressed optimism over the lower daily caseloads the Great Lakes State reported. He said he believes both cases and hospitalizations have plateaued and will likely decline soon. The professor commented: “[COVID-19] positivity has been declining now for one week, which is usually a leading indicator of case decline.”

Meanwhile, the state cited younger populations and youth sports, such as basketball, wrestling and hockey, to increase new COVID-19 infections. Because of this, Gov. Gretchen Whitmer called to suspend youth sports and indoor dining in the state. She also exhorted high schools to conduct remote class sessions for two weeks to curb the spread of the pathogen.

Michigan still experienced the spike in cases despite having one of the highest vaccination rates in the country

During the opening stages of the U.S.’s immunization drive against COVID-19, Michigan boasted of having one of the highest vaccination rates nationwide. A report by Bridge Michigan even noted the initial “frenzy for vaccines” that “far exceeded the state’s limited supply.” But things have appeared to turn around for Michigan, as it now struggles to reach the 70 percent vaccination rate needed for herd immunity.

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Scottish mom’s legs turn into a pair of “giant blisters” after first dose of AstraZeneca’s coronavirus vaccine

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(Natural News) Sarah Beuckmann of Glasgow, Scotland, felt a tingling sensation in her legs and noticed a rash flaring up around her ankles a week after getting her first dose of AstraZeneca’s coronavirus (COVID-19) vaccine on March 18.

She also had flu-like symptoms right after the vaccination.

Beuckmann called her doctor to arrange an appointment the morning she noticed the rash, but by the afternoon her skin was already breaking out into blood-filled blisters. Blisters also appeared on her legs, hands, face, arms and bottom.

“I ended up asking my husband to take me to A&E,” said Beuckmann, referring to “accident and emergency,” the equivalent of an emergency room (ER). “When I got there, my heart rate was sitting at 160bpm, which they were very concerned about. I got put on an ECG machine.”

Doctors determine AstraZeneca’s COVID-19 vaccine triggers the rash

Medics carried out tests for HIV, herpes and other skin conditions to work out what triggered the rash, but all results came back negative. Doctors finally determined that the vaccine caused her rare reaction after carrying out two biopsies.

“Once they found that it was a reaction to the vaccine, they put me on steroids and that really seems to be helping my progress,” said Beuckmann. She had been advised by her doctor not to get the second dose of AstraZeneca’s COVID-19 vaccine because of her reaction.

Beuckmann spent 16 days at Queen Elizabeth University Hospital. She was discharged to recover at home. The 34-year-old mother of one is currently wheelchair-bound due to the bandages on her legs and blisters on the soles of her feet. She may need physiotherapy to help strengthen her leg muscles.

“They are starting to heal and they’re looking a lot better than they were but as the blisters started to get worse, they all sort of merged together,” she said. “I didn’t know what was going on.”

With the blisters merging, her legs have looked like a pair of “giant blisters.” Beuckmann admitted that at one point she feared her legs might have to be amputated.

Dermatologist agrees COVID-19 vaccine causes the blisters

Dr. Emma Wedgeworth, a consultant dermatologist and spokeswoman at the British Skin Foundation, agreed that Beuckmann had likely suffered a reaction to the vaccine.

“Vaccines are designed to activate the immune system. Occasionally people will have quite dramatic activation of their immune systems which, as happened in this case, can manifest in their skin” Wedgeworth told MailOnline. “This poor lady had a very severe reaction, which thankfully is extremely rare.”

It is not clear why Beuckmann, who works in retail, was invited for a vaccine. Scotland’s vaccine rollout was focused on people over the age of 50 when she got vaccinated, although vaccines are available to those who are considered at risk from the virus, or live with someone considered vulnerable.

At least 20 million Briton have had AstraZeneca’s COVID-19 vaccine, which drug regulators say causes a rash in one percent of cases. They say rashes caused by the jab tend to go away within a week.

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Trojan labs? Chinese biotech company offers to build COVID testing labs in six states

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In 2012, BGI acquired Complete Genomics, a DNA sequencing company and equipment maker. The funds for the $117.6 million purchase were raised from Chinese venture capitals. The company has expanded its footprint globally. According to its website, BGI conducts business in more than 100 countries and areas and has 11 offices and labs in the U.S.

People are concerned about China’s access to American DNA data

Some said that with Complete Genomics providing an American base, BGI would have access to more DNA samples from Americans, helping it compile a huge database of genetic information. Some also worried about the protection of the genetic information’s privacy.

According to a 2019 report from the U.S.–China Economic and Security Review Commission (USCC), BGI “has formed numerous partnerships with U.S. healthcare providers and research organizations to provide large-scale genetic sequencing to support medical research efforts,”

There are three main reasons why many people in the biotech community and government have expressed concerns about China’s access to American DNA data.

In the “60 Minutes” interview, Evanina discussed the very likely scenario in which Chinese companies would be able to micro-target American individuals and offer customized preventative solutions based on their DNA.

Evanina asked: “Do we want to have another nation systematically eliminate our healthcare services? Are we okay with that as a nation?”

The second concern is that China may use DNA to track and attack American individuals. As the USCC report states: “China could target vulnerabilities in specific individuals brought to light by genomic data or health records. Individuals targeted in such attacks would likely be strategically identified persons, such as diplomats, politicians, high-ranking federal officials or military leadership.”

The third concern is that China may devise bioweapons to target non-Asians. Steven Mosher, president of the Population Research Institute, discussed it in his article “What Will China Do With Your DNA?” published by The Epoch Times in March 2019.

He wrote: “We know that the Asian genome is genetically distinct from the Caucasian and African in many ways. … Would it be possible to bioengineer a very virulent version of, say, smallpox, that was easily transmitted, fatal to other races, but to which the Chinese enjoyed a natural immunity? … Given our present ability to manipulate genomes, if such a bio-weapon can be imagined, it can probably – given enough time and resources – be realized.”

An article from Technocracy said: “China’s aggressive collection of American DNA should be doubly alarming because it can only spell one ultimate outcome: biowarfare. That is, genetically engineering viruses or other diseases that will be selectively harmful to U.S. populations.”

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